IFN-γ down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo

Oba, Mariko; Yano, Shuichiro; Shuto, Tsuyoshi; Suico, Mary Ann; Eguma, Ayaka; Kai, Hirofumi

doi:10.3892/ijo_32_6_1317

Cited by 7 publications

(2 citation statements)

References 1 publication

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“… 78 Glioblastoma hTERT-siRNA and IFN-γ Inhibit angiogenesis and tumor progression through the downregulation of molecules involved in these processes. 79 Lung cancer Hyperthermia and IFN-γ Suppress the basal, the heat shock-induced and the cisplatin-induced expression of Hsp27 in tumor cells and suppress tumor growth in vivo. 80 Oral squamous carcinoma Hyperthermia and IFN-γ Suppress the basal, the heat shock-induced and the cisplatin-induced expression of Hsp27 in tumor cells and suppress tumor growth in vivo.…”

Section: The Implication Of Ifns In Cancer Therapymentioning

confidence: 99%

Double-edged effects of interferons on the regulation of cancer-immunity cycle

et al. 2021

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Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was revealed that IFN signaling plays critical roles in the success of cancer therapy strategies, thereby enhancing their therapeutic effects. However, IFNs have minimal or even adverse effects on cancer eradication, and mediate cancer immune escape in some instances. Thus, IFNs have a double-edged effect on the cancer immune response. Recent studies suggest that IFNs regulate each step of the cancer immunity-cycle, consisting of cancer antigen release, presentation of antigens and activation of T cells, trafficking and infiltration of effector T cells into the tumor microenvironment, and recognition and killing of cancer cells, which contributes to our understanding of the mechanisms of IFNs in regulating cancer immunity. In this review, we focus on IFNs and cancer immunity and elaborate on the roles of IFNs in regulating the cancerimmunity cycle.

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Section: The Implication Of Ifns In Cancer Therapymentioning

confidence: 99%

Double-edged effects of interferons on the regulation of cancer-immunity cycle

et al. 2021

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“…36 A meta-analysis demonstrates that Hsp27 expression can be a strong biomarker to predict the poor clinicopathological and prognostic characteristics as well in patients with NSCLC tumors. 37 Considering the differential expression of Hsp27 in lung tumors including NSCLC; its association with the advancement of tumors and anti-cancer resistance to conventional therapies; 38 targeting this chaperone can be a potential anticancer therapeutic strategy.…”

Section: Hsp27mentioning

confidence: 99%

Heat shock proteins as biomarkers of lung cancer

Mittal

Rajala

2020

Cancer Biology & Therapy

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Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance. In recent years, heat shock proteins are gaining much importance in the field of cancer research owing to their potential to be key determinants of cell survival and apoptosis. Lung cancer is one of the most common cancers diagnosed worldwide and the association of heat shock proteins in lung cancer diagnosis, prognosis and as drug targets remains unresolved. The aim of this review is to draw the importance of heat shock protein members; Hsp27, Hsp70, Hsp90, Hsp60 and their diagnostic and prognostic implications in lung cancer. Based on the available literature heat shock proteins can serve as biomarkers and anticancer drug targets in the management of lung cancer patients.

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Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: an exploratory study

Real¹,

Castro

Cuello-Carrión

et al. 2017

Cell Stress and Chaperones

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Neoadjuvant (or induction) chemotherapy can be used for cervical cancer patients with locally advanced disease; this treatment is followed by radical surgery and/or radiation therapy. Cisplatin is considered to be the most active platinum agent drug for this cancer, with a response rate of 20%. In order to understand how the cisplatin treatment affects the stress response, in this work, we performed an exploratory study to analyze a number of stress proteins before and after cisplatin neoadjuvant chemotherapy. The study involved 14 patients; the pre- and post-chemotherapy paired biopsies were examined by hematoxylin and eosin staining and by immunohistochemistry. The proteins evaluated were p53, P16/INK4A, MSH2, nuclear protein transcriptional regulator 1 (NUPR1), and HSPB1 (total: HSPB1/t and phosphorylated: HSPB1/p). These proteins were selected because there is previous evidence of their relationship with drug resistance. The formation of platinum-DNA adducts was also studied. There was a great variation in the expression levels of the mentioned proteins in the pre-chemotherapy biopsies. After chemotherapy, p53 was not significantly affected by cisplatin, as well as P16/INK4A and MSH2 while nuclear NUPR1 content tended to decrease (p = 0.056). Cytoplasmic HSPB1/t expression levels decreased significantly following cisplatin therapy while nuclear HSPB1/t and HSPB1/p tended to increase. Since the most significant changes following chemotherapy appeared in the HSPB1 expression levels, the changes were confirmed by Western blot. The platinum-DNA adducts were observed in HeLa cell in apoptosis; however, in the tumor samples, the platinum-DNA adducts were observed in morphologically healthy tumor cells; these cells displayed nuclear HSPB1/p. Further mechanistic studies should be performed to reveal how HSPB1/p is related with drug resistance. When the correlations of the markers with the response to neoadjuvant chemotherapy were examined, only high pre-chemotherapy levels of cytoplasmic HSPB1/p correlated with a poor clinical and pathological response to neoadjuvant cisplatin chemotherapy (p = 0.056) suggesting that this marker could be useful opening its study in a larger number of cases.

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IFN-γ down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo

Cited by 7 publications

References 1 publication

Double-edged effects of interferons on the regulation of cancer-immunity cycle

Double-edged effects of interferons on the regulation of cancer-immunity cycle

Heat shock proteins as biomarkers of lung cancer

Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: an exploratory study

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