Ifosfamide-based Chemotherapy for Recurrent or Metastatic Hemangiopericytoma

Çeli̇k, İsmai̇l; Başçil, Neslihan; Yalçın, Şuayib; Güllü, İbrahi̇m; Kars, Ayse; Barışta, İbrahim; Tekuzman, Gülten

doi:10.3109/02841869709001277

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…In four children with huge unresectable lesions at diagnosis, tumor shrinkage induced by chemotherapy permitted subsequent surgery to be performed. Previous reports have documented a significant response rate to chemotherapeutic regimens in use for soft tissue sarcomas, including combinations of vincristine, actinomycin‐D, cyclophosphamide, ifosfamide, adriamycin, and dacarbazine 19–22. Even if the role of chemotherapy is not entirely clear yet, most investigators consider HPC a relatively chemosensitive neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma in pediatric ages

Ferrari

Casanova

Bisogno

et al. 2001

Cancer

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BACKGROUND Hemangiopericytoma (HPC) is very uncommon in childhood and comprises two different clinical entities, the adult type and the infantile type, occurring in the first year of age. We report on a series of 27 pediatric patients treated from 1978 to 1999 by the Italian and German Soft Tissue Sarcoma Cooperative Group. METHODS Seven patients had infantile HPC; complete resection was achieved in the tumors of five patients and chemotherapy was given to four patients. Twenty children had adult type HPC; nine received complete tumor resection (four patients at diagnosis and five at delayed surgery). Post‐operative radiotherapy was administered to 15 patients, chemotherapy to 19. RESULTS Six of seven patients with infantile HPC were alive in first remission; one patient died of disease. Chemotherapy achieved an objective response in four of four patients. Among the adult type HPC cases, 5‐year event free survival was 64% (median follow‐up 125 months); 12 patients were alive in first remission, eight patients relapsed and died of disease. Seven of 10 evaluable patients showed good response to chemotherapy. Statistically significant differences in outcome were observed in relation to Intergroup Rhabdomyosarcoma Study grouping, size, local invasiveness, and gender. CONCLUSIONS Infantile HPC is a unique entity probably related to infantile myofibroblastic lesions and characterized by a high response to chemotherapy, which is required in case of unresectable, life‐threatening tumors. In children over 1 year of age, HPC behaves like its adult counterpart; complete surgical resection remains the mainstay of treatment, but chemotherapy and radiotherapy seem effective and are recommended in all patients with incomplete tumor resection and/or locally invasive, large tumors. Cancer 2001;92:2692–8. © 2001 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma in pediatric ages

Ferrari

Casanova

Bisogno

et al. 2001

Cancer

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“…This can be attributed to the rarity of this tumor and the insufficient number of patients for randomized trials. Nevertheless, previous reports have documented a significant favorable response rate to chemotherapy of soft tissue sarcomas, including HPC [5,[12][13][14][15]. The role of radiotherapy in achieving local control after incomplete surgical removal seems to be established in the majority of reports [10].…”

Section: Discussionmentioning

confidence: 97%

HEMANGIOPERICYTOMA IN AN ADOLESCENT GIRL: A Case Report

Athanassiadou¹,

Kourti²,

Papageorgiou³

et al. 2004

Pediatric Hematology and Oncology

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Hemangiopericytoma (HPC) is a rare soft tissue tumor The few published reports account for the little information available on its clinical management. Here the authors report the successful treatment of an adolescent girl with rare HPC of the tongue. After incomplete surgical excision of the tumor she was admitted to the Hematology-Oncology Department and was treated with a 3-drug combination regimen (ifosfamide, actinomycin D, vincristine) for 8 weeks. She achieved partial remission in week 9 based on the magnetic resonance imaging (MRI)findings. Conventional radiation therapy was initiated at week 9 and continued until week 16. At week 20, according to the MRI findings, she achieved complete remission and continuation therapy was initiated. The young girl has been alive without evidence of the disease for the last 3 years of follow-up. In conclusion, the current report indicates that in cases of incomplete surgical excision of the tumor, chemotherapy and radiotherapy seem to be effective.

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