IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Chen, Lei; Al-Kzayer, Lika’a Fasih Y.; Liu, Tingting; Kobayashi, N.; Nakazawa, Yozo; Koike, Kenichi

doi:10.1002/pbc.26236

Cited by 16 publications

(13 citation statements)

References 14 publications

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“…This case had stage IV disease involving retroperitoneal and inguinal lymph nodes, the nasopharynx, spleen, lung, intestine, and parameninges with an abnormal karyotype of 46,XY,del(6)(q13q23),del(11)(p11.2p15)[21]/46,XY[1]. Although not all IRF4 translocations can be demonstrated with current techniques and some reports have described pediatric Waldeyer ring lymphomas with IRF4/MUM1 overexpression lacking these gene rearrangements, the high stage, aggressive disease in this patient is not suggestive of a large B‐cell lymphoma with IRF4 rearrangement.…”

Section: Resultsmentioning

confidence: 99%

IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials

Chisholm

Mohlman

Liew

et al. 2019

Pediatric Blood & Cancer

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Large B‐cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B‐cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.

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Section: Resultsmentioning

confidence: 99%

IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials

Chisholm

Mohlman

Liew

et al. 2019

Pediatric Blood & Cancer

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“…As we reported recently, B-cell lymphomas involving the Waldeyer’s ring had distinctive clinicopathological characteristics in pediatric patients compared to adult counterparts. A subset of cases belonged to the new entity of IRF4/MUM1 positive lymphoma 26, 27 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features

Chen

Wang

Fan

et al. 2017

Sci Rep

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Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms and complex radiological findings. However, studies that describe the clinical and radiological features of different subtypes among Chinese pediatric and adult patients are limited. We analyzed the clinical, radiological and pathological features of 31 pediatric lymphomas involving the mediastinum, and compared them to the features of 21 adult patients. Although several histological subtypes were identified in adults, pediatric patients presented with T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia (T-LBL/T-ALL) and classical Hodgkin lymphomas (CHL) in 24 and 7 cases, respectively. Compared to adults, pediatric patients were more likely to be male (P = 0.089) and showed a higher incidence of T-LBL/T-ALL (P = 0.001), prevalence of dyspnea (P = 0.001), frequency of stage IV tumors (P = 0.008), and ratio of tumor diameter to maximum transthoracic diameter (P = 0.015). T-LBL/T-ALL patients presented with a higher frequency with stage IV disease (P = 0.000 and P = 0.001), compression of the blood vessels (P = 0.005 and P = 0.017), and pleural effusions (P = 0.001, for both) than CHL and PMBL patients. Compared to adults, pediatric patients with mediastinal lymphomas presented with exclusive histological subtypes of T-LBL/T-ALL and CHL, which showed distinctive characteristics of histological distribution, clinical presentation and radiological assessments.

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“…No clinical case series of LBCL with IRF4 rearrangement have been described so far so that the clinical characteristics of children and adolescents need to be extracted from the original genetically defined cohort, a series of genetically analyzed FL cases of the tonsils and a few case reports. Altogether, 17 children and adolescents with IRF4 break confirmed by fluorescence in situ hybridization (FISH) could be detected and six entirely follicular lymphoma with IRF4/MUM1 and BCL6 co‐expression …”

Section: Large B‐cell Lymphoma With Irf4 Rearrangementmentioning

confidence: 99%

“…Tonsillar involvement was present in 13 cases with IRF4/MUM1 and BCL6 expression and/or IRF4 break. All of these patients had localized disease …”

Section: Large B‐cell Lymphoma With Irf4 Rearrangementmentioning

confidence: 99%

Rare mature B‐cell lymphomas in children and adolescents

Woessmann

Quintanilla-Martı́nez

2019

Hematological Oncology

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Pediatric-type follicular lymphoma (PTFL), pediatric nodal marginal zone lymphoma (pnMZL), and large B-cell lymphoma (LBCL) with IRF4 rearrangement have been introduced into the current World Health Organization (WHO) classification. They account for 5% to 10% of mature B-cell lymphomas in children and adolescents. Both PTFL and pnMZL predominantly affect male adolescents and usually present with localized lymphadenopathy in the head and neck region. The cells within the follicles of PTFL typically show high-grade cytology, IGH monoclonality and lack the t(14;18) chromosomal alteration. In contrast, pnMZL is characterized by progressive transformation of germinal center (PTGC)-like features and interfollicular proliferation of the cells with expansion of the marginal zones with diffuse areas. Watch and wait after complete resection seems an adequate therapy with chemotherapy restricted to incompletely resected disease. All children with PTFL and pnMZL reported, so far, survived. B-cell lymphomas presenting in the Waldeyer's ring are characterized by the expression of IRF4/MUM1 and often associated with IRF4 rearrangements. Because of the frequent diffuse component, treatment often follows current protocols for mature B-NHL. The prognosis is excellent. Follicular lymphoma (FL) in children differs from the adult counterpart clinically, morphologically, immunophenotypically, and genetically. 1

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IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Cited by 16 publications

References 14 publications

IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials

IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials

Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features

Rare mature B‐cell lymphomas in children and adolescents

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