IgA Anti-gliadin Antibodies in the Monitoring of Gluten Challenge in Celiac Disease

Valletta, E. A.; Trevisiol, D.; Mastella, G

doi:10.1097/00005176-199002000-00004

Cited by 16 publications

(16 citation statements)

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“…As already observed in our previous study (4) and also by other authors (9), gliadin antibodies showed an early increase above the normal level; at 7 days as many as five cases (42%) showed a significant increase in titre. The trend for IgG and IgA showed no major differences.…”

Section: Discussionsupporting

confidence: 90%

Immunologic and Intestinal Permeability Tests as Predictors of Relapse during Gluten Challenge in Childhood Coeliac Disease

Troncone

Caputo

Micillo

et al. 1994

Scandinavian Journal of Gastroenterology

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Fifteen children with an initial diagnosis of coeliac disease underwent gluten challenge either because they had never had a jejunal biopsy or because they had had one during the first 2 years of life. The challenge was preceded by a biopsy; clinical symptoms, the cellobiose/mannitol permeability test, and gliadin and endomysial antibody measurement were used to determine the timing of the confirmatory biopsy: it was performed if one test result was repeatedly abnormal or two results were concomitantly abnormal. Gliadin antibodies increased early (already 7 days after the reintroduction of gluten to the diet), but in many cases they returned to normal values thereafter. Increased intestinal permeability to sugars and even more positivity of endomysial antibody were good predictors of histologic relapse. The sequential use of laboratory tests during gluten challenge may significantly shorten its duration.

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Section: Discussionsupporting

confidence: 90%

Immunologic and Intestinal Permeability Tests as Predictors of Relapse during Gluten Challenge in Childhood Coeliac Disease

Troncone

Caputo

Micillo

et al. 1994

Scandinavian Journal of Gastroenterology

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“…A gluten-containing diet providing 5 to 15 g/day of gliadin caused symptoms in 59% of children within 45 days of challenge [40]. About 32% of adolescents with diagnosed or suspected CD who received at least 10 g/day of gluten for 2.4 months to 2 years experienced abdominal symptoms at the time of appearance of antireticulin-IgA [41].…”

Section: Resultsmentioning

confidence: 99%

The Clinical Response to Gluten Challenge: A Review of the Literature

Bruins

2013

Nutrients

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The aim of this review was to identify, evaluate and summarize all relevant studies reporting on the clinical response to gluten challenge by adult or pediatric patients with suspected or diagnosed coeliac disease (CD) on a gluten-free diet. We evaluated the effect of gluten challenge on changes in symptoms, intestinal mucosa histology, and serum antibodies. A systematic electronic search was performed for studies published as of 1966 using PubMed and Scopus databases. In the reviewed studies, doses ranged from 0.2 to 30 g/day of wheat gluten or comprised a gluten-containing diet. The onset of symptoms upon gluten intake varied largely from days to months and did not parallel serum antibody or histological changes. Within 3 months of gluten challenge, 70%–100% of pediatric CD patients became positive for AGA-IgA and EMA-IgA antibodies and 50%–70% for AGA-IgG. A limited number of trials suggest that no more than half of adult patients developed positive AGA-IgA, EMA-IgA, tTG-IgA or DGP-IgA/IgG titers. Approximately 50%–100% of pediatric and adult patients experienced mucosal relapse of gluten provocation within 3 months, which was preceded by increased mucosal intra-epithelial lymphocytes within several days of challenge. A 3-month high-dose gluten challenge should be suitable to diagnose the majority of CD patients. In some cases prolonged challenge may be needed to verify diagnosis. Combination testing for antibodies and mucosal histology may fasten the diagnosis.

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“…At present, two methods have been widely used to achieve a conclusive diagnosis of persistent gluten intolerance: the dosage of serum levels of AGA (GRECO et al, 1987;MAYER et al, 1989;VALLETTA et al,1990;BURGIN-WOLFF et al, 1991), and the observation of small intestinal biopsies by conventional histology (JUTo et al, 1985;KHosoo et al, 1988;MONTGOMERY et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Scanning Electron Microscopy of the Small Intestine during gluten-Challenge in Celiac Disease.

Magliocca¹,

Bonamico

Petrozza

et al. 1992

Archives of Histology and Cytology

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IgA Anti-gliadin Antibodies in the Monitoring of Gluten Challenge in Celiac Disease

Cited by 16 publications

References 0 publications

Immunologic and Intestinal Permeability Tests as Predictors of Relapse during Gluten Challenge in Childhood Coeliac Disease

Immunologic and Intestinal Permeability Tests as Predictors of Relapse during Gluten Challenge in Childhood Coeliac Disease

The Clinical Response to Gluten Challenge: A Review of the Literature

Scanning Electron Microscopy of the Small Intestine during gluten-Challenge in Celiac Disease.

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