IgA antiglomerular basement membrane disease associated with bronchial carcinoma and monoclonal gammopathy

Monoclonal IgG1κ Anti–Glomerular Basement Membrane Disease: A Case Report

“…4,5 These autoantibodies almost always are polyclonal immunoglobulin G (IgG), with rare reported cases of polyclonal IgA-mediated or monoclonal gammopathy-associated anti-GBM disease. [6][7][8] In kidney biopsy specimens, smooth linear staining for IgG is seen exclusively along the GBM, and the most common histologic pattern is severe necrotizing and crescentic glomerulonephritis. 9 Treatment involves cyclophosphamide, high-dose corticosteroids, and/or plasmapheresis.…”

Binding Truths: Atypical Anti−Glomerular Basement Membrane Disease Mediated by IgA Anti−Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen

“…Among 53 patients who presented with anti-GBM disease in 2 local renal units over the past 3 decades, this has been the only case of IgA-mediated disease that we have encountered. So far, only 13 cases have been reported in the literature 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16. In all cases, the histology was consistent with crescentic glomerulonephritis and demonstrated linear GBM staining with IgA.…”

Anti-glomerular basement membrane nephritis with bronchial carcinoma: a case report

“…9 Nevertheless, the outcomes of patients with anti-GBM nephritis combined with malignant tumor seem rather poor. In the case reports by Sugiyama et al 5 and Maes et al, 6 one patient was dialysis-dependent and the other died within 1 month after disease onset. However, our patient was not dialysis-dependent and his urine output remained normal during treatment.…”

“…Maes et al. 6 reported the presence of IgA anti-GBM disease associated with bronchial carcinoma and monoclonal gammopathy. In these patients, the comorbid conditions were more likely to be coincidental.…”