IgA-Dominant Postinfectious Glomerulonephritis

Mascarenhas, R.S.; Fogo, Agnes B.; Steele, Russell W.; Baliga, Radhakrishna

doi:10.1177/0009922815608279

Cited by 3 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then, the disease has been increasingly reported, but remains relatively rare. The largest series published to date encompass 10–20 patients, and the first attempt to pool data, in 2015, gathered less than 100 cases [48,49,50,51,52]. IgA-dominant postinfectious glomerulonephritis has been associated with Staphylococcal infections, but also with Escherichia coli , Enterococcus, and other pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…IgA-dominant postinfectious glomerulonephritis has been associated with Staphylococcal infections, but also with Escherichia coli , Enterococcus, and other pathogens. For this reason, the generic term “postinfectious” is generally used [48,49,50,51,52]. To the best of our knowledge, no case has so far been associated with Treponema infection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association

Guillen

Silva

González

et al. 2019

JCM

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Based on hypertension and nephrotic proteinuria, she was initially diagnosed with PE. Immunological tests, as well as hepatitis and HIV tests showed negative results. However, secondary syphilis was diagnosed. In discordance with the PE diagnosis, urinalysis showed glomerular microhematuria with cellular casts. Proteinuria and hypertension did not remit after delivery, which was made via caesarean section, due to uncontrolled hypertension, at an estimated gestational age of 29 weeks. A male baby, weighing 1.1 kg (6.5 centile) was born. The baby was hospitalized in the neonatal intensive care unit, where he developed subependymal hemorrhage and thrombocytopenia, and neonatal syphilis was diagnosed. The mother underwent a kidney biopsy one week after delivery, leading to the diagnosis of IgA-dominant postinfectious glomerulonephritis. Mother and child were treated with support and antibiotic therapy, and were discharged in good clinical conditions four weeks later. Four months after delivery, the mother was normotensive without therapy, with normal kidney function and without hematuria or proteinuria. In conclusion, this case suggests that IgA-dominant postinfectious glomerulonephritis should be added to the spectrum of syphilis-associated glomerulonephritides, and underlines the need for a careful differential diagnosis with CKD in all cases of presumed PE. While diagnosis relies on kidney biopsy, urinary sediment, a simple and inexpensive test, can be the first step in distinguishing PE from other nephropathies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association

Guillen

Silva

González

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…In addition, previous reports have shown that 43% of adult patients with IgA-dominant IRGN had persistent renal dysfunction and 41% progressed to end-stage renal disease (ESRD) (Haas et al 2008). Although IgA-dominant IRGN has been reported to occur in healthy children and to be associated with sequelae of renal function (Rus et al 2015;Mascarenhas et al 2016;Srinivasaraghavan et al 2016;Shirai et al 2020;Takase et al 2020;Saghar et al 2022), robust diagnostic and therapeutic strategies for IgA-dominant IRGN have not been established.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Pediatric IgA-Dominant Infection-Related Glomerulonephritis

Takagi,

Kano,

Oda

et al. 2024

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

The concept of infection-related glomerulonephritis has been introduced as adults diagnosed with glomerulonephritis often have coexisting active infections. Furthermore, IgA-dominant infection-related glomerulonephritis is associated with staphylococcal infections in adults with comorbidities, which often progress to end-stage renal disease. Little is known about IgA-dominant infection-related glomerulonephritis in children, and no consensus for a management strategy of this condition has been reached. We describe the case of a 9-year-old boy with IgA-dominant infection-related glomerulonephritis that was diagnosed using specific staining for nephritis-associated plasmin receptor (NAPlr)/plasmin activity and galactose-deficient IgA1 (Gd-IgA1), a marker of IgA nephropathy. The patient was successfully treated using a combination of prednisolone, mizoribine (an immunosuppressive drug), and lisinopril (an angiotensin-converting enzyme inhibitor) and three courses of methylprednisolone pulse therapy. The patient was admitted to our hospital with generalized edema, gross hematuria, proteinuria, hypertension, and renal dysfunction.Hypocomplementemia contributed to a diagnosis of IRGN, although the causative organism was unknown. A renal biopsy performed when the patient presented with nephrotic syndrome showed IgA deposition, positive staining for NAPlr, and negative staining for Gd-IgA1, in addition to findings consistent with infection-related glomerulonephritis, leading to a pathologic diagnosis of IgA-dominant infection-related glomerulonephritis. The histological A c c e p t e d M a n u s c r i p t 3 staining for NAPlr/plasmin activity and Gd-IgA1, together with clinical symptoms, could be helpful for diagnosing IgA-dominant infection-related glomerulonephritis. Our findings indicate that otherwise healthy children can also develop IgA-dominant infection-related glomerulonephritis. Therefore, early diagnosis and aggressive treatment should be considered when IgA-dominant infection-related glomerulonephritis is suspected to avoid the possibility of incomplete recovery of renal function.

show abstract

“…IgA PIGN has been linked to staphylococcal infections but also to infections with other pathogens including E. coli , Enterococcus species and HIV. This type of glomerulonephritis therefore appears to be postinfectious [ 6 – 10 ]. Pharyngitis has been superseded by skin, urinary or pulmonary infections [ 6 , 11 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

A rare case of Immunoglobulin A dominant post-infectious glomerulonephritis (IgA PIGN) in a young patient

Saghar¹,

Klaus²,

Trutnau³

et al. 2022

BMC Nephrol

View full text Add to dashboard Cite

Background Immunoglobulin A dominant postinfectious glomerulonephritis (IgA PIGN) is a unique medical entity that is rare in the paediatric population. It usually presents with severe renal failure, heavy proteinuria, hypertension, and hypocomplementemia and frequently has an unfavourable prognosis. IgA PIGN generally occurs in association with staphylococcal infections and diabetes mellitus in adult patients. Other pathogens include Escherichia coli and Streptococcus sp. Immunofluorescence studies of kidney biopsy samples show IgA as dominant or codominant antibody. Case presentation We encountered a 3-year-old girl with IgA PIGN presenting with acute renal failure, oedema, hypertension, and heavy proteinuria of 7955 mg/g creatinine. Renal biopsy specimens showed diffuse glomerular endocapillary hypercellularity with prominent neutrophil and monocyte infiltration on light microscopy. Strong deposits of IgA and C3 were observed along the glomerular basement membranes and the mesangium by immunofluorescence microscopy, and electron microscopy revealed the presence of subepithelial humps. The patient was managed with steroid (and probatory antibiotic) therapy and is now undergoing follow-up, with a significant improvement 6 months after the initial presentation (glomerular filtration rate (GFR) and cystatin C clearance rate of 165 ml/min/1.73m2 and 106 ml/min/1.73m2, respectively). No signs of bacterial infection were detectable. Conclusion This variant of IgA PIGN must be distinguished from other clinical entities, especially IgA nephropathy (mesangial IgA deposits) and postinfectious glomerulonephritis (C3, IgG and occasional IgM capillary loop deposits with or without mesangial distribution), since patients with IgA PIGN may require steroid treatment in addition to antibiotic therapy. Differential diagnosis should also include C3 glomerulopathy. IgA PIGN is a recently identified disease entity that generally manifests in adult patients with both IgA and C3 mesangial and glomerular capillary wall deposits. We present a biopsy-proven case of IgA PIGN that manifested in a patient at an exceptionally young age and that has had a good clinical outcome. To the best of our knowledge, this is the youngest IgA PIGN patient reported thus far.

show abstract

IgA-Dominant Postinfectious Glomerulonephritis

Cited by 3 publications

References 15 publications

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association

Pediatric IgA-Dominant Infection-Related Glomerulonephritis

A rare case of Immunoglobulin A dominant post-infectious glomerulonephritis (IgA PIGN) in a young patient

Contact Info

Product

Resources

About