IgA levels are predictors of mortality in Finnish nonagenarians

Hurme, Mikko; Paavilainen, Paula; Pertovaara, Marja; Jylhä, Marja; Karhunen, Pekka J.; Hervonen, Antti; Lehtimäki, Terho

doi:10.1016/j.mad.2005.02.005

Cited by 27 publications

(14 citation statements)

References 7 publications

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“…Hurme et al [10] have also reported that IgA levels are predictors of mortality. They measured the IgA levels in a cohort of 285 ninety-yearold Finnish and found that the IgA levels are higher in the female of nonsurvivors than in survivors, but they did not study the causes of the deaths [10] .…”

Section: Discussionmentioning

confidence: 95%

“…It has been thought that the increased IgA and subclass of IgG in healthy aged people may confer greater protection against viral and bacterial infections [9] . Recently, Hurme et al [10] have reported that IgA levels are significantly higher in nonsurviving females in a 4-year follow-up study of Finnish nonagenarians and they claimed that IgA levels are a predictor of mortality, which was novel and different from previous ideas. Therefore, we measured serum immunoglobulin levels (IgA, IgG and IgM) in older people and investigated the relation between these immunoglobulin levels and mortality.…”

Section: Introductionmentioning

confidence: 87%

“…Hurme et al [10] did not investigate the causes of the deaths; therefore, we have investigated the relation between immunoglobulin levels and cause of death. Because cancer, cardiovascular disease and pneumonia are the 3 major causes of death in older Japanese [8,11] , we analyzed the relationship between these 3 diseases and immunoglobulin levels.…”

Section: Introductionmentioning

confidence: 99%

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IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population

et al. 2008

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Background: Immunoglobulin levels are elevated in the older people. However, it is unknown whether these levels are related to mortality. Object: To evaluate the association between immunoglobulin levels and mortality. Methods: The study population included 697 individuals (277 males and 420 females) of 1,282 eighty-year-old individuals residing in the Fukuoka prefecture, Japan. The participants were followed for 4 years after the baseline examination. Results: The hyper-IgA group, defined as a serum IgA level >400 mg/dl, had high mortality using Kaplan-Meier analysis (log rank, p = 0.037). Multivariate Cox regression analyses revealed a high risk of mortality (hazard rate = 1.233, 95% confidence interval 1.109–1.491, p = 0.031) after adjusting for covariates. The high risk of mortality in the hyper-IgA group was significant in males, but not in females. Moreover, Kaplan-Meier analysis revealed that IgA was related to cancer mortality in males (log rank, p = 0.031), but not to pneumonia or cardiovascular disease. IgM and IgG levels were not related to high risk of mortality. Conclusion: Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population

et al. 2008

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“…The last two were highest and related to greater mortality. Particularly, IgA, reactive protein C (RPC), and IL-6 are index of intestinal inflammation and/ or a defect in mucosal defence [35].…”

Section: B Lymphocytesmentioning

confidence: 99%

Acquired immunity: immunosenescence and physical activity

Malaguarnera

Cristaldi

Lipari

2008

Eur Rev Aging Phys Act

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Several lines of evidence indicate that infectious diseases, cancer, and autoimmune disorders occur more frequently in elderly people, thus suggesting that altered function of immune organs and cells, such as thymus and T and B lymphocytes are of primary importance in the pathogenesis of these diseases. Furthermore, old subjects are less responsive to vaccine than younger because of immune changes. The most common changes accompanying the adaptive immune system include decrement of T and B cells proliferation, repertoire degeneracy, increase of the memory cell type, decreased numbers of naive cells, and shift from T helper 1 (Th1) to T helper 2 (Th2) response. Regular exercise in the elderly may improve the alterations in acquired immunity which follow the physiological process of aging, allowing a major resistance against external pathogens and a better quality of life.

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“…Many changes, involving systems, apparatuses and organs, occur during this continuous process. The immune function is also involved, thereby contributing to the increased susceptibility to infections, cancer and autoimmunity diseases [31].…”

Section: Introductionmentioning

confidence: 99%

The role of exercise on the innate immunity of the elderly

Cristaldi

Vinci

Malaguarnera

2007

Eur Rev Aging Phys Act

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The increased life span in human population has shown that some diseases, as infections, cancer and autoimmune phenomena, occur more frequently in the elderly than in the younger. We describe the ageing process involving the innate immune system and the improvement given by moderate physical activity. In addition, we discuss the altered neutrophil granulocytes function, the role of macrophages and natural killer cells, besides the influence of cytokines and secretory IgA. The acquired information help us to explain how these changes could favor the onset of diseases in the elderly and how they may boost their immune function.

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IgA levels are predictors of mortality in Finnish nonagenarians

Cited by 27 publications

References 7 publications

IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population

IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population

Acquired immunity: immunosenescence and physical activity

The role of exercise on the innate immunity of the elderly

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