IgA-mediated autoimmune hemolytic anemia

Azevedo, Fernando Santos de; Fernandes, Helder; Silva, Anderson Ricardo Santos da; Barbosa, Alexandre Domingues; Correia, Anabela; Alves, R. Pinto

doi:10.1016/j.ejim.2013.08.425

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“…Data on acquired hemolytic anemia or hemophilia anemia (acquired factor VIII deficiency) and CRP are limited, and until now, notably elevated CRP levels have been reported during other underlying medical conditions, yet there have been patients reported with significantly increased CRP values possibly in relapses. There also exist scarce data on common variable immunodeficiency and X-linked agammaglobulinemia subjects, yet a study found that those cases have higher CRP values, predisposing them to a high CVD risk [ 676 , 677 , 678 , 679 , 680 ]. CRP, in parallel with autoimmune myelofibrosis, is not as studied [ 681 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

View full text Add to dashboard Cite

show abstract

IgA-mediated autoimmune hemolytic anemia

Cited by 1 publication

References 0 publications

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

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