IgA Nephropathy Associated with Hepatitis B Virus Antigenemia

Lai, Kar Neng; Lai, Fernand Mac‐Moune; Lo, Stephen T.H.; Ho, Carmen Tze Kwan; Chan, Kin Wai

doi:10.1159/000184477

Cited by 25 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HBV has long been known to be associated with a variety of glomerular diseases including membranous glomerulonephritis, membranoproliferative glomerulonephritis and mesangial proliferative glomerulonephritis (4-9). In addition, polyarteritis nodosa and immunoglobulin A nephropathy have also been associated with chronic HBV infection (10)(11)(12)(13). First described in 1971 by Combes et al (4), MGN is the most commonly associated renal disorder, with epidemiological studies subsequently confirming its association with HBV.…”

Section: Discussionmentioning

confidence: 99%

Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Gan

Devlin

Scott-Douglas

et al. 2005

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

Membranous glomerulopathy is a well-recognized extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The authors report two cases of HBV-related nephrotic syndrome treated with lamivudine. A 46-year-old Chinese man had a hepatitis B e antigen seroconversion along with improvement in his nephrotic syndrome after lamivudine therapy. Two years after treatment was discontinued, a reactivation of HBV was successfully treated again with lamivudine. A 44-year-old Chinese woman, who was intolerant of interferon, was treated with lamivudine for 15 months without a virological response. However, two years after completing lamivudine, her nephrotic syndrome resolved. Implications for the treatment of HBV-related glomerulopathy and a review of the literature are presented.

show abstract

Section: Discussionmentioning

confidence: 99%

Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Gan

Devlin

Scott-Douglas

et al. 2005

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…[18][19][20][21] In addition, other authors have suggested IgA nephropathy to be associated with certain types of microorganisms. [22][23][24][25][26] In particular, deposits of Haemophilus parainfluenzae-related proteins have been demonstrated in kidney tissue specimens from Japanese patients with IgA nephropathy. Patients with IgA nephropathy have also been suggested to have significantly higher levels of IgA antibody specific to Haemophilus parainfluenzae than did patients with other glomerular diseases.…”

Section: Discussionmentioning

confidence: 99%

Increased expression of HLA-DR molecule on peripheral blood Th lymphocytes from patients with IgA nephropathy

Tanaka

Kaneoka

Kuroiwa

et al. 1999

Clinical and Experimental Nephrology

View full text Add to dashboard Cite

Background. IgA nephropathy is the commonest type of glomerulonephritis. Recent studies have shown a decrease in the expression of HLA class I antigens on peripheral blood mononuclear leukocytes (PBML) from patients with HLA class II-associated autoimmune diseases. In this study, the expression of HLA molecules on T cells from patients with IgA nephropathy was examined in order to investigate the immunological events contributing to the pathogenesis of this disorder. Methods. Thirty Japanese patients with IgA nephropathy were studied. Nine patients with membranous nephropathy and 21 sex-and age-matched healthy individuals were enrolled as controls. Heparinized PBML with or without stimulation by an anti-CD3 monoclonal antibody were analyzed in regard to the expression of HLA-class I, HLA-DR, CD4, CD8, CD11a, CD11b, and CD56, by two-color fluorescence flow cytometry. Results. The expressions of HLA-class I, HLA-DR, CD11a, CD11b, and CD56 on resting CD3-positive, CD4-positive, CD8-positive, or CD20-positive cells from patients with IgA nephropathy were found to be comparable with those from the controls. However, after stimulation by anti-CD3 antibody, the expression of HLA-DR on CD4-positive cells from these patients was significantly higher than that from the controls. Further, the expression of HLA-DR on CD4-positive cells from patients with proteinuria of more than 1 g/day was much higher than that in patients with proteinuria of less than 1 g/day. Conclusions.In this study, the expression of HLA-DR on stimulated Th cells from IgA nephropathy patients was shown to be significantly higher than the expression in the stimulated T cells from the controls. This finding suggests that Th cells may acquire antigen-presenting activity by HLA-DR expression, present antigens to other Th cells, promote B cells to produce antibodies, and, presumably, lead to the development of IgA nephropathy.

show abstract

“…All three major hepatitis B virus antigens, including HBsAg, HBeAg, and HBeAg, had been localized in glo merular capillary wall or measangium [7,8,12,[15][16][17], This could suggest a mechanism involving hepatitis B virus antigen containing immune complexes which result from passive trapping or local immune complex forma tion at this site. However, the presence of hepatitis B virus antigens in the glomerulus also could be a result of non specific passive trapping and not responsible for the glo merular lesion [3], Circulating immune complexes need to be very small and cationic to penetrate the basement membrane via the subepithelial space [18].…”

Section: H Epatitis B Virus Associated G Lom Erulonephrit Ismentioning

confidence: 99%

Treatment of Hepatitis B Virus Associated Glomerulonephritis with Recombinant Human Alpha Interferon

Chung

Yang²,

Kim³

et al. 1997

Am J Nephrol

View full text Add to dashboard Cite

To evaluate the therapeutic effect of recombinant human α-interferon (α-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of pro-teinuria, the hepatitis B viral markers and urinary protein were monitored during α-IFN treatment in 8 male adult patients who (1) were positive in serum HBsAg and HBeAg, (2) had chronic hepatitis, (3) had persistent proteinuria > 1 g/day, and (4) showed glomerulonephritis on kidney biopsy, α-IFN was given at a dose of 3 million units, subcutaneously, three times a week for 6 months. Kidney biopsy specimens showed membranoproliferative glomerulonephritis (MPGN) in 4 patients, mesangial proliferative glomerulonephritis (MesPGN) in 2, and membranous glomerulonephritis (MGN) in 2 patients. Seven of the 8 patients received a 6-month course of α-IFN therapy; 1 patient with MGN quitted therapy 2 months after the initial dose because of side effects. In 5 of the 7 patients who received a 6-month therapy, serum HBeAg disappeared, and anti-HBe appeared during the therapy. In 2 of these 5 patients, HBeAg reappeared, in 1 during α-IFN therapy and in 1 9 months after the last dose of α-IFN. The hepatitis B viral markers of the patient who received a 2-month therapy did not change. HBs antigenemia persisted in all patients. In all 4 patients with MPGN, serum HBeAg was transiently or persistently converted to negative, but the proteinuria persisted. Both patients with MesPGN showed remission of proteinuria; however, only 1 patient had seroconversion of HBeAg. In 2 patients with MGN, proteinuria persisted. In conclusion, α-IFN at the doses given was not effective in MPGN type of HBV-GN. Improvement of proteinuria was achieved in MesPGN patients without disappearance of HBs antigenemia which is the finding against the possible role of HBsAg in the pathogenesis of this type of HBV-GN.

show abstract

IgA Nephropathy Associated with Hepatitis B Virus Antigenemia

Cited by 25 publications

References 6 publications

Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Increased expression of HLA-DR molecule on peripheral blood Th lymphocytes from patients with IgA nephropathy

Treatment of Hepatitis B Virus Associated Glomerulonephritis with Recombinant Human Alpha Interferon

Contact Info

Product

Resources

About