IgA nephropathy with anti-neutrophil cytoplasmic antibody seropositivity

Huang, Xinyi; Wang, Y; Xie, Liang; Zhang, Y; Tang, Sha; Yin, Shankai; Gao, Xin; Cai, Jingyi; W, Wang; Zhang, J; Zhao, Jinghong; Huang, Yunjian; Y, Li

doi:10.5414/cn108571

Cited by 15 publications

(19 citation statements)

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“…Huang et al described a case series of 14 Chinese patients with IgA nephropathy and ANCA seropositivity from among 787 biopsied cases of IgA nephropathy, comprising a 2% prevalence 3. Of the 14 patients identified (12 anti-MPO ANCA, 2 anti-PR3 ANCA), only 3 had crescentic glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

ANCA and IgA glomerulonephritis all in one: prognosis and complications

et al. 2017

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We present the case of a 75-year-old Hispanic woman with known stage 3 chronic kidney disease, long-standing hypertension and type 2 diabetes mellitus who presented with right-sided abdominal pain and acute kidney injury, nephrotic range proteinuria with positive antimyeloperoxidase antibody. A renal biopsy revealed IgA nephropathy with superimposed pauci-immune antineutrophilic cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis. The patient was treated with pulse intravenous methylprednisolone, cyclophosphamide and plasmapheresis. One week after her second dose of cyclophosphamide, she was readmitted for infectious complications including influenza A respiratory infection, bacteraemia associated with diarrhoea and herpes zoster of the trunk. In this report, we review the prevalence, treatment and prognosis of coexistent IgA nephropathy and pauci-immune ANCA-associated crescentic glomerulonephritis. We propose that a reduced-dose treatment regimen should be considered in elderly patients due to their higher risk of infectious complications. Current literature suggests that this treatment approach may reduce infectious complications without compromising therapeutic efficacy.

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Section: Discussionmentioning

confidence: 99%

ANCA and IgA glomerulonephritis all in one: prognosis and complications

et al. 2017

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“…In summary, they believed that patients with IgAN and pathogenic ANCAs commonly show clinical features of rapidly deteriorating kidney disease [10]. In a different study, Yang et al [11] described the clinical and histological features, the response to treatment and the renal outcomes of 20 IgAN patients with positive serology for ANCA.…”

Section: Discussionmentioning

confidence: 99%

“…Other notable serologic markers that have been shown to correlate with severity of disease are ANCA as evaluated by Huang et al [10].…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Huang et al, 14 patients with IgAN and serological positive ANCA were reviewed to describe the clinical and histological characteristics of this patient subpopulation and assess if ANCA seropositive patients have higher odds of developing rapidly deteriorating kidney function [10]. In summary, they believed that patients with IgAN and pathogenic ANCAs commonly show clinical features of rapidly deteriorating kidney disease [10].…”

Section: Discussionmentioning

confidence: 99%

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Rapidly Progressive IgA Nephropathy: A Case Report With Review of Clinical Presentation, Prognostic Factors and Therapeutic Modalities

2016

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IgA nephropathy (IgAN) is the most common glomerulonephritis in the Western world. Generally, the diagnosis of IgAN is based on clinical history, laboratory data, and histopathological reports. The rapidly progressing and crescentic subtype is quite uncommon. The clinical picture and spectrum of severity upon presentation varies between individual cases. In this case report, we present a previously healthy 20-year-old Latin American male with anti-neutrophil cytoplasmic antibodies seropositive rapidly progressing IgAN leading to severe acute renal impairment, uremic pericarditis, and uremic encephalopathy. Prognostic markers and histopathological types of injury have been proposed as tools to assess severity of disease and in guiding therapeutic options. This case report highlights histopathological, serological, and clinical characteristics of severe IgAN.

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“…Los ANCA, principalmente ANCA-mieloperoxidasa (MPO), se han documentado tanto en pacientes con NIgA con hallazgos histológicos de glomerulonefritis rápidamente progresiva, como en pacientes sin estos hallazgos [3][4][5] . El tamizaje de ANCA en pacientes con vasculitis pauci-inmune generalmente se limita al estudio de inmunoglobulina G; sin embargo, se ha encontrado ANCA de clase IgA en ciertas condiciones, como púrpura de Henoch-Shonlein, NIgA, entre otros 6,7 .…”

Section: Revisión De La Literaturaunclassified

Glomerulonefritis rápidamente progresiva asociada a ANCA en un paciente con nefropatía por IgA, reporte de caso

Wilches

Agudelo

Gómez

et al. 2017

Rev. Colomb. Nefrol.

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ResumenLa nefropatía por IgA es la glomerulonefritis más frecuente, en la cual menos del 10% de los pacientes cursan con deterioro rápido de la función renal. Los hallazgos histológicos de este grupo semejan los de vasculitis, con presencia de semilunas y necrosis fibrinoide. La coexistencia de nefropatía por IgA y anticuerpos anticitoplasma de neutrófilo es infrecuente y no está claro el rol patogénico de estos anticuerpos en la nefropatía por IgA. A continuación, se describe un caso de un paciente con nefropatía por IgA, glomerulonefritis rápidamente progresiva y anticuerpos anticitoplasma de neutrófilo positivos y se realiza una revisión de la literatura referente al tema.Palabras clave: nefropatía IgA, glomerulonefritis rápidamente progresiva, vasculitis, ANCA, semilunas. doi: http://dx.doi.org/10.22265/acnef.4.2.272 Abstract IgA nephropathy is the most common glomerulonephritis, in which less than 10% of patients have a rapid decline of renal function. The histological findings of this group resemble those of vasculitis, with presence of crescents and fibrinoid necrosis. The coexistence of IgA nephropathy and neutrophil anti-cytoplasmic antibodies is infrequent, and the pathogenic role of these antibodies in IgA nephropathy is unclear. Here we describe a case of a patient with IgA nephropathy, rapidly progressive glomerulonephritis and neutrophil positive anti-cytoplasmic antibodies, and literature review is presented.

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IgA nephropathy with anti-neutrophil cytoplasmic antibody seropositivity

Abstract: These findings suggest not all ANCAs are involved in the pathology of IgAN. In patients with IgAN and ANCAs, identification of pathogenic vs. non-pathogenic ANCAs is recommended.

Cited by 15 publications

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ANCA and IgA glomerulonephritis all in one: prognosis and complications

ANCA and IgA glomerulonephritis all in one: prognosis and complications

Rapidly Progressive IgA Nephropathy: A Case Report With Review of Clinical Presentation, Prognostic Factors and Therapeutic Modalities

Glomerulonefritis rápidamente progresiva asociada a ANCA en un paciente con nefropatía por IgA, reporte de caso

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