IgA pemphigus

Tsuruta, Daisuke; Ishii, Norito; Hamada, Takahiro; Ohyama, Bungo; Fukuda, Shunpei; Koga, Hiroshi; Imamura, Kazuko; Kobayashi, Hiromi; Karashima, Tadashi; Nakama, Takekuni; Dainichi, Teruki; Hashimoto, Takashi

doi:10.1016/j.clindermatol.2011.01.014

Cited by 90 publications

(115 citation statements)

References 34 publications

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“…Classically, IgA pemphigus has been divided in several clinicopathological forms, including subcorneal pustular dermatosis-type, intraepidermal neutrophilic dermatosistype, and IgA pemphigus foliaceus. 17,18 Pemphigus vegetans of the IgA variant could be considered another subtype. In our second case, the linear IgG deposition along the basement membrane could point toward additional overlap with other autoimmune diseases.…”

Section: Discussionmentioning

confidence: 98%

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Wolz¹,

Camilleri

McEvoy³

et al. 2013

The American Journal of Dermatopathology

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Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.

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Section: Discussionmentioning

confidence: 98%

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Wolz¹,

Camilleri

McEvoy³

et al. 2013

The American Journal of Dermatopathology

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“…Antibodies against plakin family proteins are detected in paraneoplastic pemphigus [13]. Finally, IgA pemphigus is a subtype that is defined by the presence of IgA-class autoantibodies [14]. The autoantigen for one type of IgA pemphigus is desmocollin-1 [14].…”

Section: Diagnosis and Treatment Of Pemphigusmentioning

confidence: 98%

“…Finally, IgA pemphigus is a subtype that is defined by the presence of IgA-class autoantibodies [14]. The autoantigen for one type of IgA pemphigus is desmocollin-1 [14]. Table 1 summarizes the classification of pemphigus and its autoantigens.…”

Section: Diagnosis and Treatment Of Pemphigusmentioning

confidence: 99%

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Diagnosis and Treatment of Pemphigus

2012

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Pemphigus is an autoimmune bullous disease, in which autoantibodies react with the cell-cell adhesion structures, desmosomes, causing blisters and erosions on the oral mucosa and skin. Pemphigus is divided into two major subtypes: pemphigus vulgaris and pemphigus foliaceus. Oral corticosteroids are the primary treatment modality for pemphigus, while other therapeutic options, such as steroid pulse therapy, immunosuppressants, intravenous immunoglobulins, plasmapheresis and anti-CD20 monoclonal antibody therapy, are occasionally employed. Immunosuppressants used to treat pemphigus include azathioprine, cyclophosphamide, cyclosporine, mycophenolate mofetil and mizoribine. In this review, we summarize the current concepts of immunotherapy for the treatment of pemphigus in the Japanese population.

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“…IgA pemphigus is characterized by IgA autoantibodies to keratinocyte cell surfaces and is divided into two subtypes: subcorneal pustular dermatosis (SPD)-type and intraepidermal neutrophilic IgA dermatosis (IEN)-type (1,2). By cDNA transfection method, we previously identified desmocollin 1 as autoantigen in SPD-type (3).…”

Section: Introductionmentioning

confidence: 99%

Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis‐type IgA pemphigus

Tsuchisaka

Ishii

Hamada

et al. 2015

Experimental Dermatology

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In this study, we attempted to identify unknown autoantigen for intraepidermal neutrophilic IgA dermatosis-type IgA pemphigus by novel IgA-specific immunoprecipitation. Massspectrometry study identified polymeric immunoglobulin receptor (PIGR) as the candidate protein, and we confirmed that PIGR expressed in both epidermis and cultured keratinocytes. Eukaryotic recombinant protein of PIGR expressed in COS7 cells was reacted with both patient and normal sera, indicating that PIGR binds physiologically to IgA. To detect antigen-specific binding by IgA autoantibodies, we performed several experiments using deglycosylated PIGR and F(ab) 2 fragments from patient sera. However, these analyses suggested that patient IgA bound physiologically, but not immunologically, to PIGR. Nevertheless, our study provided two important insights. Newly developed IgAimmunoprecipitation system should be a useful tool in the future study of identification of antigens for IgA autoantibodies. Detection of epidermal PIGR in this study confirmed previous results and indicated possible immunological role of PIGR in epidermis.

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IgA pemphigus

Cited by 90 publications

References 34 publications

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Diagnosis and Treatment of Pemphigus

Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis‐type IgA pemphigus

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