IgD-Plasma Cell Leukemia Associated with Pyroglobulinemia and Pyroglobulinuria

Abstract

New pyroglobulin variants were found in a patient with a typical plasma cell leukemia. One was found in the urine and proved to be a variant of Bence-Jones’ protein with a molecular weight of approximately 68,000. The other was found in the serum and appears to be the myeloma protein of IgD. Furthermore, an ultrastructural study disclosed myeloma cells in both peripheral blood and bone marrow to have cytoplasmic fibrils which might be unique for plasma cell leukemia.

Immunoglobulin D: Properties, Measurement, and Clinical Relevance

“…A monoclonal IgD had antibody activity against triglycerides, and the patient had hyperlipidemia (127). Another monoclonal IgD had pyroglobulin activity (precipitated irreversibly at 56°C) (153). Finally, an increased serum viscosity of 6.8 U (reference, Ͻ1.8 U) was reported for a monoclonal IgD (117).…”

IgD Plasma Cell Leukemia and Uterine Malignant Mixed Müllerian Tumor

“…Only a few IgD PCL cases have hither to been described in the literature and four of them occurred without any previously known history of myeloma (the 'de novo' or 'primary' PCL) [1,3,[8][9][10][11][12], The patient described here differed from the majority of the PCL cases, both in the course of the disease as in the response to treatment. Most remarkable was the relatively long survival, 20 months after starting treat ment.…”