IgD-receptor (IgD-R) cross-linking partially protects murine T cells from dexamethasone-induced apoptosis

Tamma, Seetha M. Lakshmi; Coico, Richard

doi:10.1189/jlb.1002492

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…The studies of interaction of secreted IgD with T cells postulated a putative IgD receptor on a small fraction of T cells in human peripheral blood and mouse peripheral lymphoid organs, which binds to N‐linked carbohydrate moieties of IgD (67, 68). Crosslinking of IgD receptor on T cells was shown to protect T cells from apoptosis (69). It has also been shown that this IgD receptor could promote the formation of immune synapse between cognate T cells and naive B cells that express transmembrane IgD and thereby augment antigen presentation and antibody production (70, 71).…”

Section: Distribution Of Igd In Humansmentioning

confidence: 99%

New insights into the enigma of immunoglobulin D

Chen

Cerutti

2010

Immunological Reviews

114

154

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SummaryImmunoglobulin D (IgD) has remained a mysterious antibody class for almost half a century. IgD was initially thought to be a recently evolved Ig isotype expressed only by some mammalian species, but recent discoveries in fishes and amphibians demonstrate that IgD was present in the ancestor of all jawed vertebrates and has important immunological functions. The structure of IgD has been very dynamic throughout evolution. Mammals can express IgD through alternative splicing and class switch recombination (CSR). Active cell-dependent and T-cell-independent IgM-to-IgD class switching takes place in a unique subset of human B cells from the upper aerodigestive mucosa, which provides a layer of mucosal protection by interacting with many pathogens and their virulence factors. Circulating IgD can bind to myeloid cells such as basophils and induce antimicrobial, inflammatory, and B-cell-stimulating factors upon cross-linking, which contributes to immune surveillance but also inflammation and tissue damage when this pathway is overactivated under pathological conditions. Recent research shows that IgD is an important immunomodulator that orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

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Section: Distribution Of Igd In Humansmentioning

confidence: 99%

New insights into the enigma of immunoglobulin D

Chen

Cerutti

2010

Immunological Reviews

114

154

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“…However, cellassociated IgD includes transmembrane IgD, intracellular IgD, and secreted IgD bound to various cell types. Crosslinking of IgD receptor on T cells was shown to protect T cells from apoptosis (Tamma and Coico 2003). It has also been shown that this IgD receptor could promote the formation of immune synapse between cognate T cells and naïve B cells that express transmembrane IgD and thereby boost antigen presentation and antibody production (Wu et al 1999;Tamma et al 2001).…”

Section: Discovery Of Igdmentioning

confidence: 99%

Role of IgD in prevention and treatment of SARS CoV-2 infection “The Hidden Soldier"

Sheir

2020

MBJ

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COVID-19 presents varied clinical features, ranging from asymptomatic, mild, to acute respiratory distress syndrome (ARDS). People of any age can be infected by the novel coronavirus but some people are at more risk than others of becoming seriously ill with COVID-19. Older people, and people with pre-existing medical conditions (such as asthma, diabetes, and heart disease) appear to be more vulnerable developing severe or even lethal illness. Children can be infected with SARS-CoV-2, and become ill with COVID-19. However, they appear to be less susceptible to infection than adults and their symptoms are generally milder. Immunoglobulin D (IgD) has remained an enigmatic antibody class since its discovery more than 50 years ago. The function of secreted IgD has been a longstanding puzzle in immunology. In this pandemic, it is the proper time to rediscover its role and find additional therapy to vaccine. In this article I will review IgD discovery, its role in immunity, its concentration in some groups and their susceptibility to infection with COVID 19.

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“…Crosslinking of surface-bound IgD on basophils by anti-IgD antibodies induces calcium influx, the secretion of B cell activating cytokines, and the release of antimicrobial factors (Chen et al, 2009;Sechet et al, 2003). Oligomeric IgD can activate T cells, while partially preventing B cells from corticosteroid-induced apoptosis (Lakshmi Tamma et al, 2001;Tamma and Coico, 2003;Wu et al, 1999). There is evidence that IgD binds to respiratory bacteria and their products (Chen et al, 2009; Forsgren and Grubb, 1979;Samuelsson et al, 2007).…”

Section: Introductionmentioning

confidence: 95%