IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Ansotegui, Ignacio J.; Melioli, Giovanni; Canonica, Giorgio Walter; Caraballo, Luis; Villa, Elisa; Ebisawa, Motohiro; Passalacqua, Giovanni; Savi, Eleonora; Ebo, Didier G.; Gómez, René Maximiliano; Luengo, Olga; Oppenheimer, John; Jensen‐Jarolim, Erika; Fischer, David A.; Haahtela, Tari; Antila, Martti; Bousquet, Jean; Cardona, Victòria; Chiang, Wen Chin; Demoly, Pascal; DuBuske, L.M.; Ferrer, Marta; Wijk, Roy Gerth van; Díaz, Sandra Nora González; Gonzalez‐Estrada, Alexei; Járes, Edgardo; Kalpaklıoğlu, Ayşe Füsun; Tanno, Luciana Kase; Kowalski, Marek L.; Ledford, Dennis K.; Monge-Ortega, Olga Patricia; Almeida, Mário Morais de; Pfaar, Oliver; Poulsen, Lars K.; Pawankar, Ruby; Renz, Harald; Romano, Antonino; Filho, Nelson Augusto Rosário; Rosenwasser, Lanny J.; Borges, Mario A. Sánchez; Scala, Enrico; Senna, G; Sisul, Juan Carlos; Tang, Mimi L.K.; Thong, Bernard Yu‐Hor; Valenta, Rudolf; Wood, Robert A.; Zuberbier, Torsten

doi:10.1016/j.waojou.2019.100080

Cited by 345 publications

(343 citation statements)

References 227 publications

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“…Presently, the standard diagnostic methodologies targeting immunoglobulin biomarkers are largely based on antibodies. Thus, infection-generated IgG and IgM are detected from serum and plasma samples by sandwich ELISA or lateral flow immunoassays; the detection of the extraordinary IgG antibody expression caused by cancer and autoimmune disease is determined by sandwich immunoassays [176]; and conventional determinations of IgE also employ antibody-based sandwich ELISA, RAST (Radio Allergo-Sorbent Test in serum) or immunoblot tests [51].…”

Section: Discussionmentioning

confidence: 99%

Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications

Bognár

Gyurcsányi

2020

IJMS

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Nucleic acid aptamers show clear promise as diagnostic reagents, as highly specific strands were reported against a large variety of biomarkers. They have appealing benefits in terms of reproducible generation by chemical synthesis, controlled modification with labels and functionalities providing versatile means for detection and oriented immobilization, as along with high biochemical and temperature resistance. Aptamers against immunoglobulin targets—IgA, IgM, IgG and IgE—have a clear niche for diagnostic applications, therefore numerous aptamers have been selected and used in combination with a variety of detection techniques. The aim of this review is to overview and evaluate aptamers selected for the recognition of antibodies, in terms of their design, analytical properties and diagnostic applications. Aptamer candidates showed convincing performance among others to identify stress and upper respiratory tract infection through SIgA detection, for cancer cell recognition using membrane bound IgM, to detect and treat hemolytic transfusion reactions, autoimmune diseases with IgG and detection of IgE for allergy diseases. However, in general, their use still lags significantly behind what their claimed benefits and the plethora of application opportunities would forecast.

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Section: Discussionmentioning

confidence: 99%

Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications

Bognár

Gyurcsányi

2020

IJMS

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“…In previous studies, the total IgE level was high among ACO patients, and similar to FeNO, this measure was considered as a biomarker for detecting eosinophilic in lammation in COPD patients [18,25]. However, these studies included patients with a history of asthma, atopic dermatitis, and allergic rhinitis that could have increased the total IgE level, regardless of COPD [26]. In this trial, an IgE cut-off value of 300 IU/mL was used in accordance with the reference range of our medical laboratory, which was higher than that used previously [18].…”

Section: Discussionmentioning

confidence: 99%

Short-term responses to high-dose inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease with a fractional nitric oxide concentration over 35 parts per billion: A single-centre pre–post study

Shiroshita¹,

Tanaka²,

Nakashima³

et al. 2020

Arch Asthma Allergy Immunol

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Introduction: There is currently no strategy for identifying chronic obstructive pulmonary disease (COPD) patients whose pulmonary function could benefit from inhaled corticosteroids. We investigated whether a 28-day regime of inhaled corticosteroids improved pulmonary function test results among COPD patients with a fractional exhaled nitric oxide concentration > 35 parts per billion. Methods: This single-centre one-arm pre–post trial included COPD patients with a fractional exhaled nitric oxide concentration > 35 parts per billion treated at our institution from September 2018 to August 2019. Patients were administered budesonide (200 μg, 8 puffs daily) for 28 days. The primary outcome measure was the difference between the forced expiratory volume in 1 s (FEV1) at baseline and after 28 days of inhaled corticosteroid treatment. Secondary outcomes included differences in COPD Assessment Test scores, %FEV1, and that between the percent forced vital capacity (%FVC) at baseline and after 28 days of treatment. Results: Twenty patients completed the 28-day inhaled corticosteroid regime. The mean difference in FEV1 between day 1 and day 28 was 340 mL (95% confidence interval: −100 to 770 mL; p = 0.122). The mean differences in secondary outcomes were: %FVC, −0.16% (95% confidence interval [CI]: −2.84 to 2.53%; p = 0.905); %FEV1, 1.63% (95%CI: −4.56 to 7.81%; p = 0.589); COPD Assessment Test score, −2.50 (95%CI: −5.72 to 0.72; p = 0.121). Conclusion: The 28-day course of inhaled corticosteroids yielded no significant difference in FEV1 for COPD patients with a fractional exhaled nitric oxide concentration > 35 parts per billion. Trial registration: University Hospital Medical Information Network Center, UMIN000034005. Registered 3 September 2018, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000038557

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“…All the patients were ordered to suspend the medications that could interfere with the test results (antihistamines, thricycles antidepressants and tranquilizers, beta-blockers, corticosteroids) the necessary days for each medication. 22,23 The clinical results were analyzed using descriptive statistics with Statistical Package for the Social Sciences (SPSS Ver22). The results were expressed in absolute frequency and percentages, stander deviation for its analysis and frequency tables and graphs were made where study variables were included.…”

Section: Methodsmentioning

confidence: 99%

Allergenic Sensitization to pollen extracts in allergic patients. General “Calixto García” University Hospital, 2017.

González¹,

Concepción²,

Flores

et al. 2020

Preprint

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Background: Nowadays, the allergic diseases are affecting the population at worldwide level and Cuba does not escape to this, inside the aeroallergens that trigger the crises we can find the pollens. The main goals of this study were to determine the allergenic sensitization to pollens in allergic patients and their relationship with the presence of allergic diseases.Methods: A cross-sectional descriptive observational study was performed in patients suffering from asthma, rhinitis, allergic rhino-conjunctivitis, atopic dermatitis and allergic conjunctivitis. All patients underwent an allergic clinical history and skin prick test with allergenic extracts of Helianthus annus, Cosmos bipinnatus, Cynodon dactylon, Quercus sp, Eucalyptus sp . Frequencies and percentages were determined for its analysis.Results: Thirty-three patients were studied. The average age was found in the third decade of life, with a predominance in women. More than half of the patients were sensitized to pollens and 24.24% of them were polysensitized; the most frequent pollen was the cynodon dactylon . The patients with rhinitis were the most sensitized with the pollens.Conclusions: There is sensitization to pollen in our patients.

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IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Cited by 345 publications

References 227 publications

Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications

Aptamers against Immunoglobulins: Design, Selection and Bioanalytical Applications

Short-term responses to high-dose inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease with a fractional nitric oxide concentration over 35 parts per billion: A single-centre pre–post study

Allergenic Sensitization to pollen extracts in allergic patients. General “Calixto García” University Hospital, 2017.

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