IgE Antibody Studies in a Case of Generalized Allergic Reaction to Human Insulin

Child, D F; Johansson, S. G. O.

doi:10.1111/j.1398-9995.1984.tb01984.x

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The presence of specific IgG and IgE insulin antibodies which do not cause clinical manifestation is common (40% and 10%, respectively), but primary clinical allergy to human insulin is exceptional (21). The antigenic determinant recognized by the antibody induced by human insulin may also be present in bovine and porcine insulin (3,10,11). Patients have also been reported to show greater sensitivity to human insulin than porcine insulin on skin testing (9).…”

Section: Discussionmentioning

confidence: 99%

Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization

Chng¹,

Leong²,

Loh³

1995

Allergy

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Primary systemic allergy to human insulin is rare. We report a case of recurrent immediate local reactions followed eventually by generalized urticaria to recombinant human insulin (Humulin) in an insulin-dependent diabetic. Skin test to Humulin R was positive, and the patient was successfully desensitized using a modified rapid desensitization protocol. Two weeks later, he had another episode of generalized urticaria after Humulin R injection. His treatment was resumed at a lower dose, and within a week he was able to tolerate his usual regimen of insulin. To our knowledge, this is the first report of a recurrence of systemic reaction after successful desensitization.

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Section: Discussionmentioning

confidence: 99%

Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization

Chng¹,

Leong²,

Loh³

1995

Allergy

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“…type I latex allergy have also been reported [17,18]. An intradermal skin test reaction would be useful to find out whether the case is a true insulin allergy or not [19].…”

Section: Determination Of Specific Ige or Igg (Against Insulin And Admentioning

confidence: 94%

“…It has been associated with a decrease in IgE antibodies titers, although the reduction in serum IgE levels does not always prevent from the development of allergic symptoms [17]. In addition, the induction of insulin IgG antibodies leading to insulin resistance has been very rarely described as a complication of immunotherapy for insulin allergy [18].…”

Section: Management Of Insulin Allergymentioning

confidence: 99%

Allergic reactions to human insulin: a review of current knowledge and treatment options

Akıncı

Yener

Bayraktar

et al. 2009

Endocr

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“…Even though the mechanism of specific immunotherapy has not been fully elucidated, the induction of anergy or depletion of specific T cells has been suggested as well as the induction of T‐regulatory cells and the modulation of antibody production by cytokines (49). Specific immunotherapy has been associated with a fall in IgE antibodies (50). The fall in serum IgE levels, however, does not exclude the appearance of allergic symptoms (36).…”

Section: Immunologic Mechanismsmentioning

confidence: 99%

Insulin allergy: clinical manifestations and management strategies

Heinzerling

Raile

Rochlitz

et al. 2008

Allergy

138

141

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Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is suspected upon noticing immediate symptoms following insulin injections. The immediate vital implications for the patient call for prompt diagnosis and management of insulin allergy. We review current knowledge and procedures based on four diabetic patients who presented in our clinic. Insulin allergy was suspected as they showed immediate symptoms after insulin injection (urticaria, rash, angioedema, hypotension, dyspnea). A detailed allergologic work‐up was performed and adequate therapy was initiated. In three of the four patients, a specific immunotherapy was started whereas in one patient a switch to oral antidiabetics was possible and consequently initiated. By standard prick testing and measurement of specific IgE antibodies, a type 1 IgE‐mediated allergy was confirmed. After initiation of insulin immunotherapy, the symptoms completely resolved in two out three of patients and significantly improved in the third patient. The fourth patient was successfully switched to oral antidiabetics. Insulin allergy is a rare but severe condition that calls for immediate allergological work‐up. It can be managed well in close cooperation between the diabetologist and the allergologist. Specific immunotherapy is efficient and should be considered.

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IgE Antibody Studies in a Case of Generalized Allergic Reaction to Human Insulin

Cited by 6 publications

References 9 publications

Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization

Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization

Allergic reactions to human insulin: a review of current knowledge and treatment options

Insulin allergy: clinical manifestations and management strategies

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