IgE-mediated allergic responses (PP-021)

Yoo, Jisung; Kang, Yong-Sung; Lee, K.; Kim, T.; Katagiri, Takuya; Tani, Nobutaka; Atsushi, Muraguchi; Ramos, José Alberto Carlos; Chua, Kee Chaing; Cheong, Nge; Lee, B.; Estanislao, A. I.; Acosta, Patricio L.; Afaga, D.; Milo, A.; Pedro, N. San; Ramos, John Donnie A.; Almeida, Karine Cristine de; Miranda, Juliana Silva; Silva, D. A. O.; Cunha-Júnior, Jair P.; Pirovani, Carlos Priminho; Rodrigues, Lílian Cataldi; Taketomi, Ernesto Akio; Tanyaratsrisakul, Sasipa; Jirapongsananuruk, Orathai; Hales, Belinda J.; Smith, Wendy Anne; Thomas, Wayne R.; Piboonpocanun, Surapon; Smith‐Norowitz, Tamar A.; Joks, Rauno; Silverberg, J.I.; Bluth, Martin H.; Norowitz, Kevin B.; Chice, Seto; Nowakowski, M.; Durkin, Helen G.; Chan, M. A.; Gigliotti, Nicole M.; Rosenwasser, Lanny J.; Würtzen, Peter Adler; Christensen, Lars; Holm, Jens Christian; Willumsen, Nicholas; Skovsgaard, Jens Peter; Lund, Kaare; Gadermaier, Elisabeth; Flicker, Sabine; Schmitz, Peter; Valenta, Rudolf; Ndlovu, Portia; Makupe, Ian; Ncube, Sithando; Sibanda, Elopy; Aleyasin, Soheila; Karimi, Amir; Hamidi, Mehrdad; Amiri, Amir A.; Ehsaei, M. J.; Sepiashvili, Revaz; Khanferyan, R. A.; Мильченко, Н. О.; Twaroch, Teresa E; Focke, Margarete; Civaj, Vera; Balic, Nadja; Mari, Adriano; Quirce, Santiago; Spitzauer, Susanne; Swoboda, Ines; Hochwallner, Heidrun; Schulmeister, Ulrike; Focke-Tejkl, Margit; Szépfalusi, Zsolt; Campana, Raffaela; Thalhamer, Joseph; Scheiblhofer, Sandra; Horák, F.; Papadopoulos, Nikolaos G.; Herz, Udo; Tol, Eric A.F. van; Ohshima, Yusei; Yasutomi, Motoko; Shirasaki, Hideaki; Kawakita, Akiko; Mayumi, Makoto

doi:10.1093/intimm/dxq108

Cited by 1 publication

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“…Kim and Hong reported about an enhancement of affinity of a humanized monoclonal antibody after light chain shuffling (Kim and Hong 2007). For allergen-specific human IgE antibodies there is some evidence that the heavy chain determines allergen-specificity (Laffer et al 2001;Rojas et al 2004;Christensen et al 2009;Gadermaier et al 2010b). It is therefore quite possible, that the affinity of allergen-specific antibodies can be increased by shuffling of light chains.…”

Section: Affinitymentioning

confidence: 99%

Passive Immunization with Allergen-Specific Antibodies

Flicker

Gadermaier

Madritsch

et al. 2011

Vaccines Against Allergies

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The induction of allergen-specific IgG antibodies has been identified as a major mechanism responsible for the reduction of allergic inflammation in allergic patients treated by allergen-specific immunotherapy. Several studies suggest that allergen-specific IgG antibodies induced by vaccination with allergens block mast cell and basophil degranulation, IgE-facilitated allergen presentation to T cells and IgE production. The availability of recombinant allergens and technologies for the production of recombinant human antibodies allows engineering of allergen-specific antibodies which can be used for passive immunization (i.e., therapy) and eventually for the prevention of allergy (i.e., prophylaxis). This chapter summarizes data supporting the possible use of allergen-specific antibodies for treatment and prophylaxis. Finally, concrete approaches for the treatment and prevention of allergy based on blocking antibodies are envisioned.

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Section: Affinitymentioning

confidence: 99%