IgE‐mediated anaphylaxis to <i>Hippobosca equina</i> in a patient with systemic mastocytosis

Matito, Almudena; Bartolomé-Zavala, Borja; Álvarez‐Twose, Iván; Sánchez-Matas, Isabel; Escribano, Luís

doi:10.1111/j.1398-9995.2009.02270.x

Cited by 17 publications

(8 citation statements)

References 5 publications

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“…Patients with mastocytosis may develop anaphylaxis not only in response to bee and wasp stings, but also after mosquito stings and stings of Hippobosca equina, such as was reported in one patient [8].…”

Section: Mastocytosis and Anaphylaxismentioning

confidence: 93%

Update on Diagnosis and Treatment of Mastocytosis

Brockow

Ring

2011

Curr Allergy Asthma Rep

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Mastocytosis is a disorder characterized by increased numbers of mast cells in tissues. Recent clinical observations highlight the association of mastocytosis with an increased risk of anaphylaxis and underline the diversity of this disease. At the molecular level, recent studies have attempted to unravel specific gene expression profiles for activating c-kit mutations in the etiology of mastocytosis. The diagnosis may be facilitated by surrogate markers and detection of aberrant immunophenotypic surface markers. New therapeutic strategies are in development based on intracellular signal pathways, or on application of topical treatments, as are novel forms of cytoreductive therapy, including tyrosine kinase inhibitors.

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Section: Mastocytosis and Anaphylaxismentioning

confidence: 93%

Update on Diagnosis and Treatment of Mastocytosis

Brockow

Ring

2011

Curr Allergy Asthma Rep

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“…97 Anaphylaxis has also been documented after bites from mosquitoes, tsetse flies, and louse flies. 83,[98][99][100] Mastocytosis may be a relevant risk factor for anaphylactic reactions. 98,100 Relevant insect species Hematophagy has developed independently in several insect families and is also found in some non-insect arthropods such as the ticks (Table 5).…”

Section: Systemic Reactionsmentioning

confidence: 99%

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

Arzt‐Gradwohl

Sturm

Boni

et al. 2023

Preprint

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Insect venom allergy is the most frequent cause of anaphylaxis in Europe and possibly worldwide. The majority of systemic allergic reactions after insect stings are caused by Hymenoptera and among these, vespid genera induce most of the systemic sting reactions (SSR). Honey bees are the second leading cause of SSR. Depending on the global region, other Hymenoptera such as different ant genera are responsible for SSR. Widely distributed hornets and bumblebees or local vespid or bee genera rarely induce SSR. Hematophagous insects such as mosquitoes and horse flies usually cause (large) local reactions while SSR occasionally occur. This position paper aims to identify either rare or locally important insects causing SSR as well as rarely occurring SSR after stings or bites of widely distributed insects. We summarized relevant venom or saliva allergens and intended to identify possible cross-reactivities between the insect allergens. Moreover, we aimed to locate diagnostic tests for research and routine diagnosis, which are sometimes only regionally available. Finally, we gathered information on disposable immunotherapies. Major allergens of most insects were identified, and cross-reactivity between insects was frequently observed. While some diagnostics and immunotherapies are locally available, standardized skin tests and immunotherapies are generally lacking in rare insect allergy.

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“…Although humans are accidental hosts of H. equina , our observations and the current medical literature provides new reports on incidents of human infestations by this species [ 76 , 77 ]. However, the literature data concerning this subject are still scarce.…”

Section: Hostsmentioning

confidence: 99%

“…In humans, the bite of the forest fly is barely noticeable, or painless, but an increasing burning sensation with erythema may start to develop after a few hours ( Figure 3 ). To date, the available medical literature has reported only four cases of human infestations by this insect species [ 76 , 77 , 92 , 93 ]. Anaphylactic reactions, e.g., erythema, nausea, facial angioedema, vomiting, dyspnea, dizziness, or tachycardia, developed in the infested patients.…”

Section: Medical and Veterinary Importance Of Hippobosca Eq...mentioning

confidence: 99%

Hippobosca equina L. (Hippoboscidae: Hippobosca)—An Old Enemy as an Emerging Threat in the Palearctic Zone

Maślanko

Szwaj²,

Gazda³

et al. 2022

IJERPH

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Arthropods of the Hippoboscoidea superfamily are parasites of animals from various systematic groups. Mass appearances of these insects and their attacks on people are increasingly being recorded. Their parasitism has a negative effect on host well-being, as it causes feelings of agitation and irritation as well as skin itching and damage. It may result in weight loss and development of diseases in the long-term perspective. Parasites can be a potential epidemiological threat for their hosts as well. One of such parasites is a cosmopolitan species of the Hippoboscinae subfamily—Hippobosca equina. Studies have confirmed the presence of Corynebacterium pseudotuberculosis equi, Bartonella spp., and Anaplasma spp. in the organism of these insects. The frequency of anaphylactic reactions caused by H. equina attacks has been increasing. The aim of the present paper was to summarize the up-to-date knowledge of Hippobosca equina Linnaeus, 1758 due to its significance in medical and veterinary sciences as a potential vector of pathogens. Given the increasing expansion of ectoparasites, mainly related to climate change, ensuring animal welfare and human health is a priority.

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IgE‐mediated anaphylaxis to Hippobosca equina in a patient with systemic mastocytosis

Cited by 17 publications

References 5 publications

Update on Diagnosis and Treatment of Mastocytosis

Update on Diagnosis and Treatment of Mastocytosis

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

Hippobosca equina L. (Hippoboscidae: Hippobosca)—An Old Enemy as an Emerging Threat in the Palearctic Zone

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