IgE-mediated hypersensitivity to chlorhexidine among first-year dental students

Abstract

PurposeTo investigate immunoglobulin E (IgE)-mediated hypersensitivity to chlorhexidine (CHX), and association between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. MethodsParticipants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3 mL) was drawn and subjected to SIgE test to CHX; sensitisation defined as SIgE level of ≥0.10 kU A /L. ResultsFifty-eight (98.3%) participants, consisting of 69% (n = 40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. ConclusionsAlthough most participants reported no known exposure to CHX, 8.6% showed CHX sensitisation suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reactions in the future. This is a preview of subscription content, log in to check access. Access optionsInstant access to the full article PDF. Price includes VAT for MalaysiaIgE-mediated hypersensitivity to chlorhexidine among first-year dental students | SpringerLink https://

Allergische Reaktionen auf COVID-19-Impfungen – Was HNO-Ärzte wissen sollten – Teil 1: Immunologische Grundlagen von Allergien auf Impfstoffe, Immunmechanismen von allergischen und pseudoallergischen Reaktionen; Teil 2: Charakteristika der mRNA-Impfstoffe BNT162b2- und mRNA-1273 zur Prophylaxe von COVID-19 und assoziierte Immunphänomene; Teil 3: Praktische Aspekte der Prophylaxe, Diagnostik und Therapie von Allergien auf COVID-19-Impfstoffe

“…Die Häufigkeit anaphylaktischer Reaktionen hat in den letzten Jahren deutlich zugenommen [5,6]. Auch andere allergische Reaktionen auf Medikamente und Impfstoffe wurden beschrieben, insbesondere wurde über schwere Anaphylaxien auf Nahrungsmittel und Medikamente berichtet [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”