IgE Profiles of Bermuda Grass Pollen Sensitised Patients Evaluated by Phleum Pratense Allergens Phl P 1, 2, 4, 5, 6, 7, 11, 12

Rossi, Renato; Monasterolo, Giorgio; Prina, Paolo; Coco, Giuseppe; Operti, D.; Rossi, Luca

doi:10.2332/allergolint.o-07-503

Cited by 12 publications

(12 citation statements)

References 14 publications

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“…Phenological studies confirmed that C. dactylon grass contributes to a small secondary peak of airborne pollen from June to July [9]. However, the patients in the Rossi study showed six times higher specific IgE to P. pratense GP (median 48.9 kUA/L) than C. dactylon (median 8.0 kUA/L), suggesting primary sensitivity to temperate GP [12], consistent with their typical pattern of IgE reactivity with components of P. pratense GP [13,14]. Similarly, in a temperate region of Australia, 85% of GP-allergic patients from Victoria had SPT responses to the subtropical P. notatum GP [15].…”

Section: Patients From Temperate Regionsmentioning

confidence: 85%

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Grass pollen allergens globally: the contribution of subtropical grasses to burden of allergic respiratory diseases

Davies

2014

Clin Experimental Allergy

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Grass pollens of the temperate (Pooideae) subfamily and subtropical subfamilies of grasses are major aeroallergen sources worldwide. The subtropical Chloridoideae (e.g. Cynodon dactylon; Bermuda grass) and Panicoideae (e.g. Paspalum notatum; Bahia grass) species are abundant in parts of Africa, India, Asia, Australia and the Americas, where a large and increasing proportion of the world's population abide. These grasses are phylogenetically and ecologically distinct from temperate grasses. With the advent of global warming, it is conceivable that the geographic distribution of subtropical grasses and the contribution of their pollen to the burden of allergic rhinitis and asthma will increase. This review aims to provide a comprehensive synthesis of the current global knowledge of (i) regional variation in allergic sensitivity to subtropical grass pollens, (ii) molecular allergenic components of subtropical grass pollens and (iii) allergic responses to subtropical grass pollen allergens in relevant populations. Patients from subtropical regions of the world show higher allergic sensitivity to grass pollens of Chloridoideae and Panicoideae grasses, than to temperate grass pollens. The group 1 allergens are amongst the allergen components of subtropical grass pollens, but the group 5 allergens, by which temperate grass pollen extracts are standardized for allergen content, appear to be absent from both subfamilies of subtropical grasses. Whilst there are shared allergenic components and antigenic determinants, there are additional clinically relevant subfamily-specific differences, at T- and B-cell levels, between pollen allergens of subtropical and temperate grasses. Differential immune recognition of subtropical grass pollens is likely to impact upon the efficacy of allergen immunotherapy of patients who are primarily sensitized to subtropical grass pollens. The literature reviewed herein highlights the clinical need to standardize allergen preparations for both types of subtropical grass pollens to achieve optimal diagnosis and treatment of patients with allergic respiratory disease in subtropical regions of the world.

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Section: Patients From Temperate Regionsmentioning

confidence: 85%

“…Rossi et al. report IgE reactivity with allergen components of P. pratense GP in C. dactylon GP‐allergic patients from north‐west Italy. Phenological studies confirmed that C. dactylon grass contributes to a small secondary peak of airborne pollen from June to July .…”

Section: Allergic Sensitivity To Subtropical Grass Pollensmentioning

confidence: 99%

Grass pollen allergens globally: the contribution of subtropical grasses to burden of allergic respiratory diseases

Davies

2014

Clin Experimental Allergy

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“…Therefore, the “asthma‐biomarker” role of IgE to Phl p 7 is likely explained by a spurious association (Phl p 7 sensitization being a proxy of extreme polysensitization) rather than by a direct causal‐effect link. Nevertheless, the data suggest that testing IgE for Phl p 7 may be useful not only to explain cross‐reactivity, but also as a quite specific biomarker of asthma among SARg patients. Phl p 12 – IgE sensitization to Phl p 12 (profilin) was observed in over 25% of the examined patients and it was strongly associated with OAS. Our study therefore confirms that profilin is a known trigger of allergic reactions to plant‐derived foods, mostly limited to the oral cavity …”

Section: Discussionmentioning

confidence: 99%

“…Second, the relative frequency of IgE sensitization to P. pratense and other grass pollens in patients with SAR is higher in Northern than in Southern Italy . Phleum pratense is the most relevant grass pollen allergen in Italy; however, other grasses (eg, Bermuda grass, Lolium perenne ) may play in patients a role in triggering seasonal allergic symptoms . Third, the data on the SAR characteristics were based only on a retrospective questionnaire and, therefore, exposed to potential recall bias.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules

Cipriani

Mastrorilli

Tripodi

et al. 2017

Allergy

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In a large pediatric population, the complexity of IgE sensitization profiles against P. pratense molecules is related to high atopic features although useless for predicting the clinical severity. The detection of serum IgE to Phl p 1, Phl p 7, and Phl p 12 can be used as clinical biomarkers of SARg and comorbidities. Further studies in different areas are required to test the impact of different IgE molecular profiles on AIT response.

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“…Various cross-allergenicities between pollen group 4 allergens from different grass species have been demonstrated using polyclonal and monoclonal IgG and IgE antibodies of grass pollen-allergic patients. Rossi and coworkers found that the majority of 411 BGP-allergic patients were co-sensitive to native or recombinant Timothy-grass allergens, including the native Phl p 4 (Rossi et al, 2008). In contrast, neither natural Lol p 4 nor Phl p 4 bound to polyclonal murine IgG antibodies that had been raised against Cyn d 4 (Su et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Various cross-reactivity of the grass pollen group 4 allergens: crystallographic study of the Bermuda grass isoallergen Cyn d 4

Huang¹,

Peng²,

Su³

et al. 2012

Acta Crystallogr D Biol Cryst

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The structure of Cyn d 4, the group 4 allergen from Bermuda grass, is reported at 2.15 Å resolution and is the first crystal structure of a naturally isolated pollen allergen. A conserved N-terminal segment that is only present in the large isoallergens forms extensive interactions with surrounding residues and hence greatly enhances the structural stability of the protein. Cyn d 4 contains an FAD cofactor that is covalently linked to His88 and Cys152. To date, all identified bicovalent flavoproteins are oxidases and their substrates are either sugars or secondary metabolites. A deep large hydrophobic substrate-binding cleft is present. Thus, Cyn d 4 may be an oxidase that is involved in the biosynthesis of a pollen-specific metabolite. Cyn d 4 shares ~70% sequence identity with the Pooideae group 4 allergens. Various cross-reactivities between grass pollen group 4 allergens have previously been demonstrated using sera from allergic patients. The protein surface displays an unusually large number of positively charged clusters, reflecting the high pI of ~10. 38 decapeptides that cover the solvent-accessible sequences did not show any significant IgE-binding activity using sera with high Cyn d 4 reactivity from four patients, suggesting that the IgE epitopes of Cyn d 4 are predominantly conformational in nature. Several group 4 structures were then modelled and their potential cross-reactive and species-specific IgE epitopes were proposed.

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IgE Profiles of Bermuda Grass Pollen Sensitised Patients Evaluated by Phleum Pratense Allergens Phl P 1, 2, 4, 5, 6, 7, 11, 12

Cited by 12 publications

References 14 publications

Grass pollen allergens globally: the contribution of subtropical grasses to burden of allergic respiratory diseases

Grass pollen allergens globally: the contribution of subtropical grasses to burden of allergic respiratory diseases

Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules

Various cross-reactivity of the grass pollen group 4 allergens: crystallographic study of the Bermuda grass isoallergen Cyn d 4

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