IgE sensitization profiles of adult patients with moderate and severe atopic dermatitis: is there a role for molecular-based allergy diagnosis?

rBlo t 5 is a potential contributor to the severity of atopic dermatitis in a Brazilian population

“…Sensitization to rBlo t 5 (>0.7 ISU) was associated with 69% specificity and 80% sensitivity of having severe AD (Table 1) with moderate and severe AD. 9 Our study showed also high sensitization to those components (nDer p 1/nDer f 1 79.3% in the mild AD group and 90% for nDer f 1 and 86.7% for nDer p1 in severe AD group), which shows 82% amino acid sequence identity and high cross-reactivity. 10 In our study, sensitization patterns to Der p 1 and Der f 1 could not distinguish mild and severe AD patients as rBlo t 5, which shows a trend in this sense.…”