IGF-1 gene polymorphism in obese patients with insulin resistance

Yaylalı, Güzin Fidan; Akın, Fulya; Turgut, Sabahat; Kursunluoglu, Raziye

doi:10.1007/s11033-009-9729-6

Cited by 13 publications

(20 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, another study demonstrated that the homozygous carriers ( 4194 bp) among Korean women have higher serum IGF-I levels compared with noncarriers [33]. Fidan et al [10] noted that serum IGF-I level was lower in obese patients with the predominant ( 4194 bp) genotype, in contrast to our findings. However, in accordance with our above-mentioned explanation, other factors such as insulin resistance can affect serum IGF-I level in obesity.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Gene polymorphism and serum levels of insulin-like growth factor-I in Egyptian acne patients

El‐Tahlawi¹,

Abdel‐Halim²,

Hamid³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 99%

“…Noncarriers of the 192-bp alleles showed increased relative risk for type 2 diabetes and myocardial infarction [8]. The most frequent IGF-I genotype associated with obesity was the 194 bp genotype [10]. The most frequent IGF-I genotype associated with obesity was the 194 bp genotype [10].…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphism and serum levels of insulin-like growth factor-I in Egyptian acne patients

El‐Tahlawi¹,

Abdel‐Halim²,

Hamid³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

View full text Add to dashboard Cite

“…A functional relationship was found between this type of polymorphism and the circulating levels of IGF1. People with the 192 bp allele (19 repeats) or 194 (20 repeats) have higher levels of IGF1 than non-carriers of these alleles 13. Moreover, some studies have shown an association between increased levels of IGF and increased cancer risk 14,15.…”

Section: Introductionmentioning

confidence: 99%

Insulin-Like Growth Factor 1 Gene Polymorphism and Breast Cancer Risk among Arab Omani Women: A Case-Control Study

Al-Ajmi

Ganguly

Al-Ajmi

et al. 2012

Breast Cancer�(Auckl)

View full text Add to dashboard Cite

Breast cancer is the most common cancer worldwide with significant global burden. Insulin-like growth factor 1 (IGF1) is an important regulator of cellular growth, differentiation, and apoptosis and mitogenic and antiapoptotic activities. Some studies suggested an association between cytosine adenine (CA) repeats gene polymorphisms of IGF1 and the risk of developing breast cancer while other studies did not find such an association. This study aims investigate the role of IGF1 (CA) repeats gene polymorphisms in the risk of developing breast cancer among Omani women.MethodsWe analyzed (CA) repeats gene polymorphisms of IGF1 by extraction of genomic DNA from the peripheral blood of 147 patients with breast cancer and 134 control participants and performed genotyping using DNA sequencing.ResultsApproximately 46% of patients carried the IGF (CA)19 repeat allele, with 31.3% carrying two copies of this allele and 50% of controls carried the IGF (CA)19 repeat allele with 30.1% carrying two copies of this allele. The difference of the IGF CA repeat groups was significant between cases and controls with (P =0.02). In contrast, there was no difference in the distribution of (CA)19 repeat allele, (CA)18 repeat allele and (CA)19 repeat allele between cases and controls. The difference of the CA groups was significant between cases and controls among postmenopausal women with (P =0.026), whereas no difference was observed among postmenopausal subjects (P =0.429). In both pre- and postmenopausal groups there was no difference in the distribution of (CA)19 repeat allele, (CA)18 repeat allele and (CA)20 repeat allele between patients and control subjects. On further IGF1 genotypes classification, we found an association between progesterone receptor status and the genotypes group where the non carrier of (CA)19 repeat group was compared to (CA)19 repeat carrier group (OR =2.482; 95% CI =1.119–5.503; P value =0.023).ConclusionOverall there was no association between the IGF (CA)19 repeat and breast cancer in Omani females.

show abstract

“…The numbers of (CA) repeats vary between 10 and 24, whereby the Caucasian population mostly contains 19 (CA) repeats. 128,129 Genetic architecture of acne vulgaris Among 115 Turkish acne patients and 116 controls, the difference between the group was significant at >194 bp 19 CA repeats (P = 0.0002) (Tasli et al). 130 In a meta-analysis study, the Caucasian population presented a higher frequency of 19 (CA) repeats than the Asian population (65.5 vs. 33.3%) (Chen et al).…”

Section: Insulin-like Growth Factor-1 Gene (Igf-1)mentioning

confidence: 99%

Genetic architecture of acne vulgaris

Lichtenberger

Simpson

Smith

et al. 2017

Acad Dermatol Venereol

View full text Add to dashboard Cite

Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. Here, we review our current understanding of the genetic architecture of this intriguing disease. We analysed genomewide association studies (GWAS) and candidate genes studies for acne vulgaris. Moreover, we included GWAS studies for the associated disease polycystic ovary syndrome (PCOS). Overall, the available data revealed sixteen genetic loci flagged by single nucleotide polymorphisms (SNPs), none of which has been confirmed yet by independent studies. Moreover, a GWAS for PCOS identified 21 susceptible loci. The genetic architecture is complex which has been revealed by GWAS. Further and larger studies in different populations are required to confirm or disprove results from candidate gene studies as well to identify signals that may overlap between different populations. Finally, studies on rare genetic variants in acne and associated diseases like PCOS may deepen our understanding of its pathogenesis.

show abstract

IGF-1 gene polymorphism in obese patients with insulin resistance

Cited by 13 publications

References 14 publications

Gene polymorphism and serum levels of insulin-like growth factor-I in Egyptian acne patients

Gene polymorphism and serum levels of insulin-like growth factor-I in Egyptian acne patients

Insulin-Like Growth Factor 1 Gene Polymorphism and Breast Cancer Risk among Arab Omani Women: A Case-Control Study

Genetic architecture of acne vulgaris

Contact Info

Product

Resources

About