IGF-1 in gynaecology and obstetrics: update 2002

Druckmann, René; Rohr, Uwe D.

doi:10.1016/s0378-5122(02)00016-6

Cited by 83 publications

(46 citation statements)

References 135 publications

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“…A higher risk for cervical, ovarian and endometrial cancer is related to high IGF-I levels in post-and premenopausal women. Plasma IGF-I levels are higher in cases of severe endometriosis; however, in endometriosis IGF-I levels locally in the endometrium are reduced (Druckmann & Rohr 2002). …”

Section: Self-sufficiency In Growth Signalsmentioning

confidence: 99%

Endometriosis and the neoplastic process

Varma¹,

Rollason²,

Gupta³

et al. 2004

Reproduction

186

146

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Endometriosis is a frequent disorder that commonly presents with infertility and pelvic pain. Although the precise aetiology of endometriosis is unclear, it is generally considered to involve multiple genetic, environmental, immunological, angiogenic and endocrine processes. Genetic factors have been implicated in endometriosis but the susceptibility genes remain largely unknown. Although endometriosis is a benign disorder, recent studies of endometriosis suggest endometriosis could be viewed as a neoplastic process. Evidence to support this hypothesis includes the increased susceptibility to develop ovarian clear-cell and endometrioid cancers in the presence of endometriosis, and molecular similarities between endometriosis and cancer. In this article we discuss (i) the evidence suggesting that endometriosis might be viewed as a neoplastic process, and (ii) the implications of this hypothesis for elucidating the pathogenesis of endometriosis and developing novel methods of diagnostic classification and individualised treatments.

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Section: Self-sufficiency In Growth Signalsmentioning

confidence: 99%

Endometriosis and the neoplastic process

Varma¹,

Rollason²,

Gupta³

et al. 2004

Reproduction

186

146

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“…It exerts its potent mitogenic activity through increased DNA synthesis and biological actions are regulated through IGFBPs by endocrine and paracrine mechanisms. 6,7 It has been shown to act in folliculogenesis, pre-implantation embryonic development, implantation and fetal-placental growth. 7 Fibroblast growth factor (FGF) is a potent inducer of angiogenesis that is widely expressed during embryonic and fetal development and is able to act as a mitogen, a tissue morphogen and a modulator of tissue differentiation and placental angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 It has been shown to act in folliculogenesis, pre-implantation embryonic development, implantation and fetal-placental growth. 7 Fibroblast growth factor (FGF) is a potent inducer of angiogenesis that is widely expressed during embryonic and fetal development and is able to act as a mitogen, a tissue morphogen and a modulator of tissue differentiation and placental angiogenesis. 5,8 Placental expression of FGF/FGF receptors has been identified in rodents, pigs, ovine and human.…”

Section: Introductionmentioning

confidence: 99%

Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses

et al. 2008

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“…Numerous clinical and experimental data indicated that IGF-IR is involved in the tumorigenesis of breast (Surmacz, 2000), prostate (Djavan et al, 2001;Nickerson et al, 2001), pancreas (Korc, 1998), lung (Wu et al, 2000), colon (Giovannucci, 2001), liver (Scharf et al, 2001), ovary (Burroughs et al, 2002;Druckmann and Rohr, 2002), brain (Zumkeller and Schwab, 1999), and bladder (Hursting et al, 2001). The tumorigenic potential of IGF-IR usually relies on hyperactivation of IGF-I signaling.…”

mentioning

confidence: 99%

Role of the IGF‐I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progression

Mauro

Salerno

Morelli

et al. 2002

Journal Cellular Physiology

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The insulin-like growth factor-I receptor (IGF-IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF-IR signaling has been implicated in the development of different types of tumors. The strong antiapoptotic activity of IGF-IR has been recognized as critical in IGF-I-dependent tumorigenesis, however, the impact of other IGF-IR functions, such as regulation of cell-cell and cell-matrix adhesion are also increasingly acknowledged. Here, on the model of breast cancer cells, we discuss how IGF-IR-dependent regulation of intercellular adhesion may affect cell survival, resistance to antiestrogens, and invasion.

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IGF-1 in gynaecology and obstetrics: update 2002

Cited by 83 publications

References 135 publications

Endometriosis and the neoplastic process

Endometriosis and the neoplastic process

Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses

Role of the IGF‐I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progression

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