IGF‐1 TMJ injections enhance mandibular growth and bone quality in juvenile rats

Joshi, Ashwini S.; Hatch, Nan; Hayami, Takayuki; Jheon, Andrew H.; Kapila, Sunil

doi:10.1111/ocr.12524

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…4 Therefore, it is of common interest and practical need among researchers and clinicians to explore reliable approaches to promote MA-induced condylar osteogenesis. Previous studies 17,18 have found that growth hormone and local injection of insulin-like growth factor 1 can effectively promote condylar osteogenesis and growth in functional orthopaedics in growing rats. However, to date, there is no report on the pharmacological enhancement of MAinduced condylar osteogenesis in middle-aged animals.…”

Section: Discussionmentioning

confidence: 99%

Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

2023

J of Oral Rehabilitation

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Class II malocclusion manifested by mandibular deficiency destroys the facial attractiveness. 1 Promoting mandibular growth through functional orthopaedic treatments, such as mandibular advancement (MA)-induced condylar remodelling, has been shown to be effective in improving facial aesthetics. 2 However, the effect of MA-induced condylar osteogenesis varies from person to person. 3 Especially in non-growing patients, the effect of MA-induced condylar osteogenesis is still controversial. 4 Therefore, constructing

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Section: Discussionmentioning

confidence: 99%

Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

2023

J of Oral Rehabilitation

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“…Clefting defects have been successfully corrected in a murine model through in utero injection of recombinant proteins 76 . Murine models have also been used to demonstrate enhanced condylar growth through local injection of IGF‐1 and enhanced orthodontic anchorage or retention by localized delivery of osteoprotegerin 77–81 . Studies such as these serve as a proof‐of‐concept and foreshadow a future of precision orthodontics whereby the omics profile of an individual will help identify customized mechano‐ and bio‐therapeutic targets likely involving administration of small molecules or localized delivery of biomimetics/drugs identified through pharmaco‐omics to elicit a predictable and favourable orthodontic treatment response.…”

Section: Application Of Biologics and Multi‐omics In Precision Orthod...mentioning

confidence: 99%

Connecting the dots towards precision orthodontics

Kapila,

Vora,

Rengasamy Venugopalan

et al. 2023

Orthod Craniofacial Res

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Precision orthodontics entails the use of personalized clinical, biological, social and environmental knowledge of each patient for deep individualized clinical phenotyping and diagnosis combined with the delivery of care using advanced customized devices, technologies and biologics. From its historical origins as a mechanotherapy and materials driven profession, the most recent advances in orthodontics in the past three decades have been propelled by technological innovations including volumetric and surface 3D imaging and printing, advances in software that facilitate the derivation of diagnostic details, enhanced personalization of treatment plans and fabrication of custom appliances. Still, the use of these diagnostic and therapeutic technologies is largely phenotype driven, focusing mainly on facial/skeletal morphology and tooth positions. Future advances in orthodontics will involve comprehensive understanding of an individual's biology through omics, a field of biology that involves large‐scale rapid analyses of DNA, mRNA, proteins and other biological regulators from a cell, tissue or organism. Such understanding will define individual biological attributes that will impact diagnosis, treatment decisions, risk assessment and prognostics of therapy. Equally important are the advances in artificial intelligence (AI) and machine learning, and its applications in orthodontics. AI is already being used to perform validation of approaches for diagnostic purposes such as landmark identification, cephalometric tracings, diagnosis of pathologies and facial phenotyping from radiographs and/or photographs. Other areas for future discoveries and utilization of AI will include clinical decision support, precision orthodontics, payer decisions and risk prediction. The synergies between deep 3D phenotyping and advances in materials, omics and AI will propel the technological and omics era towards achieving the goal of delivering optimized and predictable precision orthodontics.

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“…Endochondral ossification is modulated by various determinants, including genetic factors [ 21 ], hormonal regulation [ 22 ], and nutritional aspects [ 23 ]. Among these factors, growth factors such as insulin-like growth factor 1 (IGF-1) [ 24 , 25 , 26 ] or growth hormone [ 27 ] were used to induce mandibular growth by local injection into temporomandibular joint cavity in experimental animals. Because these factors augment cartilage growth not only in mandibular condylar cartilage but also in the growth cartilage of limbs, local injection into the temporomandibular joint cavity is required to obtain specific mandibular growth [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Mandibular Endochondral Growth Is Specifically Augmented by Nutritional Supplementation with Myo-Inositol Even in Rabbits

Shimoyama,

Kanzaki,

Tohyama

et al. 2024

Dentistry Journal

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Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of functional appliances is not always stable in daily practices. A more effective, reliable, and safer therapeutic method for mandibular growth promotion would be helpful for growing mandibular retrognathism patients. As we previously discovered that nutritional supplementation of myo-inositol in growing mice specifically increases mandibular endochondral growth, we performed preclinical animal experiments in rabbits in this study. Briefly, six-week-old male Japanese white rabbits were fed with or without myo-inositol supplementation in laboratory chow until 25 weeks old, and 3D image analysis using micro CT data and histological examinations was done. Myo-inositol had no systemic effect, such as femur length, though myo-inositol specifically augmented the mandibular growth. Myo-inositol increased the thickness of mandibular condylar cartilage. We discovered that the nutritional supplementation of myo-inositol during the growth period specifically augmented mandibular growth without any systemic influence, even in rabbits. Our results suggest the possibility of clinical use of myo-inositol for augmentation of the mandibular growth in growing mandibular retrognathism patients in the future.

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IGF‐1 TMJ injections enhance mandibular growth and bone quality in juvenile rats

Cited by 9 publications

References 38 publications

Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

Connecting the dots towards precision orthodontics

Mandibular Endochondral Growth Is Specifically Augmented by Nutritional Supplementation with Myo-Inositol Even in Rabbits

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