IGF-I has a direct proliferative effect in adult hippocampal progenitor cells

Åberg, Maria; Åberg, N. David; Palmer, Theo D.; Alborn, Ann-Marie; Carlsson-Skwirut, Christine; Bang, Peter; Rosengren, Lars; Olsson, Torsten; Gage, Fred H.; Eriksson, Peter S.

doi:10.1016/s1044-7431(03)00082-4

Cited by 251 publications

(202 citation statements)

References 57 publications

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“…Furthermore, Ziv et al (2006) reported that environmental enrichment-induced neurogenesis in the hilus correlates with hilar microglial activation and IGF-1 expression. Finally, in cell culture assays, the effects of IGF-1 on hippocampal progenitor cell proliferation were shown to be mediated, in part, via the MAPK pathway (Aberg et al, 2003). These findings, coupled with work implicating other trophic factors (Battista et al, 2006;Walton et al, 2006) suggest that IGF-1 is one key regulator of SE-induced progenitor cell proliferation.…”

Section: Discussionmentioning

confidence: 86%

“…Next, we tested candidate growth factors as potential regulators of MAPK pathway activity in progenitor cells. Our attention centered on IGF-1 since it has been shown to both regulate the MAPK cascade and increase the rate of progenitor cell proliferation in the dentate gyrus (Aberg et al, 2000(Aberg et al, , 2003Kurihara et al, 2000). Initially, we examined the expression pattern of IGF-1 in the dentate gyrus.…”

Section: Regulation Of the Mapk Pathway By Insulin-like Growth Factormentioning

confidence: 99%

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IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

Choi

Cho

Hoyt

et al. 2008

Glia

133

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Adult progenitor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus is a dynamic process that is modulated by an array of physiological process, including locomotor activity and novel environmental stimuli. In addition, pathophysiological events, such as ischemia and status epilepticus (SE), have been shown to stimulate neurogenesis. Currently, limited information is available regarding the extracellular stimuli, receptors, and downstream intracellular effectors that couple excitotoxic stimulation to progenitor cell proliferation. Here we show that pilocarpineinduced SE triggers a set of signaling events that impinge upon the p42/44 mitogen-activated protein kinase (MAPK) pathway to drive progenitor cell proliferation in the SGZ at 2-days post-SE. Increased proliferation was dependent on insulin-like growth factor-1 (IGF-1), which was localized to activated microglia near the SGZ. Using a combination of techniques, we show that IGF-1 is a CREB-regulated gene and that SE triggered CRE-dependent transcription in microglia at 2-days post-SE. Together, these data identify a potential signaling program that couples SE to progenitor cell proliferation. SE triggers CREB-dependent transcription in reactive microglia. As a CREB-target gene, IGF-1 expression is upregulated, and by 2-days post-SE, IGF-1 triggers MAPK pathway activation in progenitor cells and, in turn, an increase in progenitor cell proliferation.

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Section: Discussionmentioning

confidence: 86%

Section: Regulation Of the Mapk Pathway By Insulin-like Growth Factormentioning

confidence: 99%

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

Choi

Cho

Hoyt

et al. 2008

Glia

133

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“…For example, brain-derived neurotrophic factor (BDNF) enhances hippocampal proliferation, an effect that is blocked by BDNF-specific antibodies. 39 Insulinlike growth factor 1 (IGF-1), 40 transforming growth factor (TGF), vascular endothelial growth factor (VGEF) and others growth factors have been shown to induce proliferation in the dentate gyrus. [41][42][43][44][45] The Wnt signaling pathway was identified to induce neurogenesis in the dentate gyrus.…”

Section: Regulation Of Adult Neurogenesismentioning

confidence: 99%

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Chesnokova¹,

Pechnick²

2008

Cell Cycle

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“…NSCs within the subgranular layer generate new granule neurons that incorporate into the dentate gyrus (15,16). Self-renewal and multipotency of SVZ-and subgranular layer-derived NSCs have been demonstrated by in vitro culture (17)(18)(19)(20)(21).…”

mentioning

confidence: 99%

Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors

Consiglio

Gritti

Dolcetta

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

159

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Stable genetic modification of adult stem cells is fundamental for both developmental studies and therapeutic purposes. Using in vivo marking studies, we showed that injection of lentiviral vectors (LVs) into the subventricular zone of the adult mouse brain enables efficient gene transfer into long-term self-renewing neural precursors and steady, robust vector expression in their neuronal progeny throughout the subventricular zone and its rostral extension, up to the olfactory bulb. By clonal and population analysis in culture, we proved that in vivo-marked neural precursors display self-renewal and multipotency, two essential characteristics of neural stem cells (NSCs). Thus, LVs efficiently target long-term repopulating adult NSCs, and the effect of the initial transduction is amplified by the continuous generation of NSC-derived, transduced progeny. LVs may thus allow novel studies on NSCs' physiology in vivo, and introduction of therapeutic genes into NSCs may allow the development of novel approaches for untreatable CNS diseases.

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IGF-I has a direct proliferative effect in adult hippocampal progenitor cells

Cited by 251 publications

References 57 publications

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

Antidepressants and Cdk inhibitors: Releasing the brake on neurogenesis?

Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors

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