IGF-I, IgA, and IgG responses to bovine colostrum  supplementation during training

Mero, Antti; Kähkönen, Jonne; Nykänen, Tarja; Parviainen, Tapani; Jokinen, Ilmari; Takala, Timo; Nikula, Tuomo; Rasi, Simo; Leppäluoto, Juhani

doi:10.1152/japplphysiol.00002.2002

Cited by 78 publications

(96 citation statements)

References 37 publications

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“…However, it was seen that there were no differences in IgA between the experimental and control groups (Table 1). Similar results (10,14,15) were obtained from some sports branches. But (7) the average values of serum IgA were estimated to be higher than the values mentioned in this research.…”

Section: Discussionsupporting

confidence: 86%

“…And it was seen that there was no difference in the serum IgG between the experimental and control groups (Table 1). Researches showed that the colostrum supplement had no effect on IgG levels in athletes (14), sportsmen (7,15) and swimmers (10). They informed that the serum IgG levels were between 6.5-16.0 g/L in adult persons (3).…”

Section: Discussionmentioning

confidence: 99%

“…Many researchers who focused on the effect of colostrum on sportsmen in their studies, dealt with its effect on serum IGF-I, IgG, hormone and saliva IgA levels in athletes (14), and on IGF-I, IgG, IgA, saliva IgA in sportsmen (15), some of them analyzed its effect on serum immunoglobulins in cyclists and its effect on saliva IgA levels in marathon runners (9,17). Researches were done to view the effect of colostrum on immunoglobulins and albumin amount in swimmers (10).…”

Section: Introductionmentioning

confidence: 99%

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The effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players

Kivrak¹,

UCAR²

2014

TJSE

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This study was done to investigate the effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players. 24 male basketball players from students at Physical Education and Sports in Selcuk University participated in this study. These players were divided into two groups including a control group of 12 persons and an experimental group of 12 persons. The sportsmen's blood samples were taken for the research three times (at 0th, 30th and 60th days), the serum immunoglobulins (IgG, IgA, IgM, IgE) and the proteins (Albumin, Globulin, Total Protein) were analyzed using standard methods. Moreover, the statistical analyses were done for the experimental and control groups in the basketball players with the SPSS 15 program and evaluated as well. When considered the results, it was determined that there were increases in the average amounts of Serum IgG, IgE, Globulin, Total Protein. However, a significant decrease was found in the Serum IgM. And it was found out that there were differences in the globulin amount and the total protein values (P<0.05) between the control and experimental groups using colostrum. In conclusion, it has been suggested that future researches on colostrum will be suitable for various sports branches and different age groups considering especially sportsmen' criteria such as immunity, regeneration, performance. Thus, the sportsmen will benefit from the outstanding characteristics of colostrum at a maximum level; the success will be achieved more in this way.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players

Kivrak¹,

UCAR²

2014

TJSE

View full text Add to dashboard Cite

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“…However, in calves, rats and piglets, oral ingestion of IGF-I has been shown to provoke various local effects on gastrointestinal tract [1,2,9,10,124,237,241], and to increase blood IGF-I concentration [8,236]. In human athletes, Mero et al [133] also showed that orally administered IGF-I increased blood IGF-I concentration but the peptide was fragmented (96%) when in circulation. Those results thus suggest that dietary IGF-I may be absorbed and cause local and systemic effects.…”

Section: Insulin-like Growth Factormentioning

confidence: 99%

Growth factors from bovine milk and colostrum: composition, extraction and biological activities

Gauthier

Pouliot

Maubois

2006

Lait

125

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-EGF, BTC, IGF-I, IGF-II, TGF-β1, TGF-β2, FGF1 and 2, and PDGF are the main growth factors present in bovine milk and colostrum. All of these growth factors are also found in human milk but at a lower concentration. The various compositional data reported in the literature vary greatly but it is evidenced that the day of lactation has the most important effect. Milk growth factors are characterized by a neutral to alkaline isoelectric point (pI) and a molecular mass between 6400 g·mol -1 and 30000 g·mol -1 . However, many of the growth factors are in a latent form, bound to high-molecular-mass proteins. Milk growth factors are resistant generally to pasteurization but disulfide reducing agents have been found to inactivate some species such as TGF-β's. The published data on bioavailability of milk growth factors are somewhat contradictory but it is generally accepted that they are resistant to gastric digestion and they can exert local and systemic effects on the gastrointestinal tract. Cation-exchange chromatography has been widely used for the extraction of milk growth factors because of the basic nature of these molecules. Membrane separations such as microfiltration (MF) have also been used successfully for the extraction of immunoglobulins and of some growth factors from colostrum, while ultrafiltration (UF) was successful only at separating IGF-I and IGF-II in whey. Milk growth factor extracts have been developed for various applications such as treatment of gastrointestinal disorders and skin diseases, wound healing, and induction of oral tolerance.

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“…1 In recent years, researchers have attempted to identify nutritional countermeasures to exercise-induced changes in IgA concentration in saliva. Effect of different kind of supplementation both on exercise induced decreases in salivary IgA and incidence of URTI , was investigated, such as glutamine [13,14], carbohydrate [9], protein [14], nucleotide [21], vitamin C [25], and bovine colostrum supplementation [5,22].…”

Section: Effect Of Sensory Stimulation On Salivary Iga Secretion Ratementioning

confidence: 99%

Effect of sensory stimulation on salivary IgA secretion rate in karate players

Baralić¹,

Miletić²,

Djordjević³

et al. 2010

Biol Sport

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ABSTRACT:Objectives: Secretory IgA is predominant immunoglobulin in secretions of the mucosal immune system. Low concentration of salivary IgA is associated with a higher risk of respiratory tract infections episodes in athletes during the training season. The purpose of this study was to determine whether orange-flavored whey based drink has beneficial effect on level of IgA in saliva after the training. Methods: Twenty healthy, young karate players participated in this study. They were divided into two groups. One group rinsed a mouth with 20 ml of liquid whey, two times in 30-min period: 15 and 30 min after training. Second group rinsed a mouth with 20 ml of whey based orange flavored soft drink, at the same time. Saliva was collected before the training, just after the training and after application of fluids. Results: We observed decrease in salivary flow after physical activity. The salivary flow was higher after the application of flavored drink compared to salivary flow after the application of whey. The absolute concentration of sIgA and sIgA secretion rate decreased just after exercise compared to pre exercise values. Application of whey elevated sIgA levels on day 1, while application of flavored drink caused increasing in sIgA levels on day 3. In all other cases sIgA level was decreasing even after applied stimuli. Conclusions: The exercise induces decreasing in salivary flow, sIgA absolute concentration and sIgA secretion rate. Application of fluid whey and flavored whey-based drink elevated salivary flow, but had little effect on absolute concentration of sIgA and sIgA secretion rate in young karate players.

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IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training

Cited by 78 publications

References 37 publications

The effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players

The effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players

Growth factors from bovine milk and colostrum: composition, extraction and biological activities

Effect of sensory stimulation on salivary IgA secretion rate in karate players

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