2001
DOI: 10.1006/dbio.2001.0208
|View full text |Cite
|
Sign up to set email alerts
|

IGF-I Synergizes with FGF-2 to Stimulate Oligodendrocyte Progenitor Entry into the Cell Cycle

Abstract: Secreted peptide growth factors are critical extracellular signals that interact to promote the proliferation, differentiation, and survival of progenitor cells in developing tissues. IGF-I signaling through the IGF type I receptor provides a mitogenic signal for numerous cell types, including stem and progenitor cells. We have utilized the O-2A oligodendrocyte progenitor to study the mechanism of IGF-I mitogenic actions since these progenitors respond to IGF-I in vitro, and gene targeting studies in mice have… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
65
0
1

Year Published

2003
2003
2016
2016

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 90 publications
(72 citation statements)
references
References 52 publications
6
65
0
1
Order By: Relevance
“…Multiple extracellular agents are known to influence progenitor cell (OPC) proliferation, differentiation and OLG survival through interaction with specific OPC or OLG receptors. These include: platelet-derived growth factor (PDGF); basic fibroblast growth factor (bFGF); insulin-like growth factor-1 (IGF-1); glial growth factor (GGF); neurotrophic factors; and ciliary neurotrophic factor (CNTF) among others (McMorris and Dubois-Dalcq 1988;Barres et al 1992;Louis et al 1993;Heinrich et al 1999;Baron et al 2000;Yan and Wood 2000;Jiang et al 2001). Separate factors, either derived from neurons, astrocytes, or synthesized locally by OLGs themselves, may also modulate OPC/OLG development through receptor-mediated mechanisms.…”
mentioning
confidence: 99%
“…Multiple extracellular agents are known to influence progenitor cell (OPC) proliferation, differentiation and OLG survival through interaction with specific OPC or OLG receptors. These include: platelet-derived growth factor (PDGF); basic fibroblast growth factor (bFGF); insulin-like growth factor-1 (IGF-1); glial growth factor (GGF); neurotrophic factors; and ciliary neurotrophic factor (CNTF) among others (McMorris and Dubois-Dalcq 1988;Barres et al 1992;Louis et al 1993;Heinrich et al 1999;Baron et al 2000;Yan and Wood 2000;Jiang et al 2001). Separate factors, either derived from neurons, astrocytes, or synthesized locally by OLGs themselves, may also modulate OPC/OLG development through receptor-mediated mechanisms.…”
mentioning
confidence: 99%
“…Oligodendrocytes (OLs), the myelinating cells of the CNS, die after spinal cord injury (SCI) at the time of impact and for several weeks thereafter (Crowe et al, 1997;Grossman et al, 2001). OL loss contributes to demyelination, which impairs axon conduction and neurological function.…”
Section: Introductionmentioning
confidence: 99%
“…IGF may play a role in oligogenesis after SCI as increased astrocytic production of IGF-1 was noted in a cryogenic SCI model [93]. Importantly, IGF can amplify the action of FGF-2 and PDGF on OPCs [94], suggesting it may increase the effectiveness of these factors if/when present after SCI. Ciliary neurotrophic factor (CNTF), a pleiotropic cytokine, is also important for OPC survival and proliferation [95,96].…”
Section: Survival and Proliferation Of Opcsmentioning
confidence: 96%