IGF1 increases blastocyst attachment to endometrial epithelial cells in vitro and regulates fibronectin expression

Green, Charmaine J; Fraser, Stuart T.; Day, Margot L.

doi:10.1530/repabs.1.p029

Cited by 1 publication

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“…Furthermore, as animal model studies have shown, the IGF-I level was elevated in response to steroid hormone stimulation. The higher level of IGF-I plays a critical role in vascular permeability, decidualization, and upregulation of implantation markers (43,44). Our results indicated low level of endometrial IGF-I in PCOS women compared to healthy fertile controls which may result in implantation failure in these patients.…”

Section: Discussionmentioning

confidence: 59%

Molecular signature of immunological mechanism behind impaired endometrial receptivity in polycystic ovarian syndrome

Amjadi¹,

Zandieh²,

Mehdizadeh³

et al. 2022

Archives of Endocrinology and Metabolism

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Objective: Despite the treatment of anovulation, infertility is still one of the main complications in PCOS women during reproductive age, which appears to be mainly due to impaired uterine receptivity. This study investigated the transcriptome profiles of endometrium in PCOS patients and healthy fertile individuals as the control group. Material and methods: Total mRNA was extracted from endometrial tissues of PCOS patients (n = 12) and healthy fertile individuals (n = 10) during the luteal phase. After cDNA synthesis, PCR array was performed using Human Female Infertility RT² Profiler PCR Array kit (Qiagen, Cat.No: PAHS-164Z) for evaluating expression of 84 genes contributing to the female infertility. Results: PCR Array data analysis identified significantly greater expression of CSF,

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Section: Discussionmentioning

confidence: 59%