IGFBP-3 and IGFBP-10 (CYR61) up-regulation during the development of Barrett's oesophagus and associated oesophageal adenocarcinoma: potential biomarkers of disease risk

Martino, Erica di; Wild, Christopher P.; Rotimi, Olorunda; Darnton, J S; Olliver, R J; Hardie, Laura J.

doi:10.1080/13547500600896791

Cited by 41 publications

(27 citation statements)

References 36 publications

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“…These two values were multiplied to yield a final staining score of between 0 and 12. In addition, cellular localisation was assessed (Di Martino et al, 2006). All sections were scored independently by two observers.…”

Section: Immunohistochemistrymentioning

confidence: 99%

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Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network

et al. 2008

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Oesophageal adenocarcinoma, which arises from an acquired columnar lesion, Barrett's metaplasia, is rising in incidence more rapidly than any other cancer in the Western world. Elevated expression of c-MYC has been demonstrated in oesophageal adenocarcinoma; however, the expression of other members of the MYC/MAX/MAD network has not been addressed. The aims of this work were to characterise the expression of c-MYC, MAX and the MAD family in adenocarcinoma development and assess the effects of overexpression on cellular behaviour. mRNA expression in samples of Barrett's metaplasia and oesophageal adenocarcinoma were examined by qRT -PCR. Semi-quantitative immunohistochemistry and western blotting were used to examine cellular localisation and protein levels. Cellular proliferation and mRNA expression were determined in SEG1 cells overexpressing c-MYCER or MAD1 using a bromodeoxyuridine assay and qRT -PCR, respectively. Consistent with previous work expression of c-MYC was deregulated in oesophageal adenocarcinoma. Paradoxically, increased expression of putative c-MYC antagonists MAD1 and MXI1 was observed in tumour specimens. Overexpression of c-MYC and MAD proteins in SEG1 cells resulted in differential expression of MYC/MAX/ MAD network members and reciprocal changes in proliferation. In conclusion, the expression patterns of c-MYC, MAX and the MAD family were shown to be deregulated in the oesophageal cancer model.

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Section: Immunohistochemistrymentioning

confidence: 99%

“…To allow semi-quantitative evaluation of protein expression, the epithelial component of each section was scored as described in the methods for intensity of immunoreactivity and percentage of epithelial cells stained (Di Martino et al, 2006) (Table 2).…”

Section: Immunolocalisation Of Myc/max/mad Network Proteins In the Prmentioning

confidence: 99%

Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network

et al. 2008

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“…5,6 Research shows that CYR61 may be regarded as both a suppressor and a promoter of cancer progression and tumour invasion. 14,17 Studies have shown that CYR61 can suppress carcinogenesis in nonsmall cell lung cancer or gastric carcinoma. 17,18 However, other studies have shown that CYR61 can enhance carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 CYR61 expression has been shown to be significantly higher in Barrett's oesophageal adenocarcinoma tissue than in Barrett's oesophageal tissue with no sign of cancer. 13,14 The significance of CYR61 expression and prognosis in ovarian epithelial cancer, however, remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Cysteine-rich, angiogenic inducer, 61 expression in patients with ovarian epithelial carcinoma

Yang

Tian

et al. 2014

J Int Med Res

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Objective: Cysteine-rich, angiogenic inducer, 61 (CYR61) is a key gene in the transforming growth factor-b signalling pathway, which is involved in the development of many tumour types. This study aimed to clarify the status and clinical significance of CYR61 expression in patients with ovarian epithelial carcinoma. Methods: Tissue from patients with ovarian epithelial carcinoma or benign ovarian tumours were investigated retrospectively for CYR61 expression at mRNA and protein levels, using reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. Correlations between immunohistochemical scores and several clinicopathological parameters were investigated. Results: In 50 patients with ovarian epithelial carcinoma and 50 patients with benign ovarian tumours, CYR61 expression on mRNA and protein levels was significantly higher in ovarian epithelial carcinoma tissue than in benign ovarian tissue. CYR61 expression was associated with regional lymph node metastases and progression of clinical disease stage. There was no difference in CYR61 expression between patients aged <50 years and !50 years. Conclusions: CYR61 expression was significantly upregulated in ovarian carcinoma tissue compared with benign ovarian tumour tissue samples. Protein CYR61 levels were associated with lymph node metastases and Union for International Cancer Control stage. Protein CYR61 may be useful in targeted diagnosis and therapy, for patients with ovarian epithelial carcinoma.

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“…Karaciğer metastazının tanı anında tümör invazyon derinliği, venöz invazyon ve lenf nodu metastazı varlığı ile yakın ilişkili olduğu gösterilmesine rağmen bu faktörlerin zayıf prediktif etkisi sebebi ile kullanımı kısıtlıdır (11)(12)(13). Bu sebeple tanı anında karaciğer metastazını predikte edecek farklı faktörler araştırılmıştır.…”

Section: Introductionunclassified

Predictive Factors Of Liver Metastasis After Curative Treatment For Colorectal Cancer

Hocazade¹,

Yıldırım²,

Bozkaya³

et al. 2016

Acta Oncol Tur.

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ÖZETGiriş ve Amaç: Kolorektal kanserler dünya genelinde en sık görülen kanserlerden biridir. Karaciğer metastazı tanıdan kısa bir süre sonra gelişebilir. Daha önce tedavi almış kolorektal kanserli hastalarda karaciğer metastazektomi yapılması 5 yıllık sağkalımı %20-40 oranında arttırabilir. Bu çalışmada erken evre kolorektal karsinomlu hastaların karaciğer nüksünü erken dönemde predikte edebilecek faktörleri araştırmayı amaçladık. Yöntem ve Gereçler: Çalışmamıza Ankara Numune Eğitim ve Araştırma Hastanesi Tıbbi Onkoloji Kliniğinde 2009 Ocak-2014 Ağustos aylarında takibe alınarak tedavi planı yapılan non-metastatik 517 hasta dahil edilmek üzere değerlendirildi. Birinci grupta karaciğer dışı nüksü olan hastalarla beraber nüks olmadan takibe devam edilen hastalar varken 2.grupta ise karaciğer metastazı gelişen hastalar mevcuttu. Hastaların tanı anındaki laboratuar sonuçları receiver operating characteristic (ROC) curve analizi uygulanarak laktat dehidrogenaz (LDH), karsinoembriyonik antijen (CEA) ve gama glutamil transferaz (GGT) için cut off değerleri belirlendi (sırasıyla, 400 U/L, 50 ng/ml ve 90 U/L). Bulgular: Univariate analizde CEA değeri yüksek olan 20 hastanın 7'sinde (%35), düşük olan 206 hastanın 28'inde (%8,7) kc metastazı gelişmişti (p<0,001). LDH değerine göre karaciğer nüksüne bakıldığında ise yüksek olan 15 hastanın 5'inde (%33,3), düşük olan hasta grubunda 189 hastadan 17'sinde (%9) takipte karaciğer metastazı gelişti (p=0,003). GGT değerine göre ise yüksek olan 15 hastanın 5'inde (%33,3), düşük olan 244 hastanın 24'ünde (%9,8) karaciğer nüksü gelişmişti (p=0,005). Multiple lojistik regresyon analizi ile değerlendirildiğinde LDH anlamlılığını korumaktaydı (p=0,047, OR 7,8: 1,02-59,3). Tartışma ve Sonuç: Karaciğer metastazı kolorektal kanser tanısı alan hastalarda surveyi etkileyen önemli bir faktördür. Bizim çalışmamızda LDH yükseliğinin karaciğer nüksünü predikte etmede kullanılabilecek uygun bir fakör olduğu görüldü fakat bu sonucun prospektif randomize çalışmalarla desteklenmesi gerekmektedir. Anahtar Kelimeler: Kolorektal kanser, karaciğer, nüks ABSTRACT Introductıon: Colorectal cancer (CRC) is one of the most commonly detected cancers worldwide. Liver metastasis might develop shortly after the diagnosis of colorectal cancer. Liver metastasectomy might improve the five year survival rate to 20-40% in patient with previously treated CRC. We aimed in this study to evaluate the predictive factors to liver metastases in patients with newly diagnosed non metastatic CRC. Methods: Five hundred and seventeen non-metastatic colorectal patients followed at Medical Oncology Department of Ankara Numune Training and Research Hospital between January 2009 and August 2014 were evaluated retrospectively. Patients were divided in to the two subgroups. Group 1 consisted of non-metastatic and metastatic patients except liver metastases. Group 2 consisted of patients with liver metastases. Laboratuary results at the time of diagnosis were evaluated with receiver operating characteristic (ROC) Curve analysis and cut...

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IGFBP-3 and IGFBP-10 (CYR61) up-regulation during the development of Barrett's oesophagus and associated oesophageal adenocarcinoma: potential biomarkers of disease risk

Cited by 41 publications

References 36 publications

Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network

Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network

Cysteine-rich, angiogenic inducer, 61 expression in patients with ovarian epithelial carcinoma

Predictive Factors Of Liver Metastasis After Curative Treatment For Colorectal Cancer

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