2006
DOI: 10.1099/jmm.0.46667-0
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IgG and IgG subclass antibodies in patients with active cutaneous leishmaniasis

Abstract: This research was planned to detect IgG and IgG subclasses in sera of patients with active cutaneous leishmaniasis (CL). Sera from 30 patients with active CL aged between 10 and 50 years and from 30 healthy controls aged between 8 and 50 years were included in the study. Levels of IgG and its subclasses were measured by a nephelometer. Levels of IgG, IgG1 and IgG3 in the CL patients were higher than in the controls. In addition, IgG and IgG1, and IgG and IgG3 levels showed a significant positive correlation. T… Show more

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Cited by 17 publications
(12 citation statements)
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“…Recently decreases in IgG1 and IgG3 after cure [59] or post-active disease scarring [60] have also been reported for Brazilian cutaneous leishmaniasis (CL), and higher levels of these IgG subclasses in Turkish patients with active CL compared to endemic controls [61] .…”
Section: Discussionmentioning
confidence: 99%
“…Recently decreases in IgG1 and IgG3 after cure [59] or post-active disease scarring [60] have also been reported for Brazilian cutaneous leishmaniasis (CL), and higher levels of these IgG subclasses in Turkish patients with active CL compared to endemic controls [61] .…”
Section: Discussionmentioning
confidence: 99%
“…Although leishmanial infections induce strong humoral responses, the role of the elevated antileishmanial antibodies in kala-azar patients towards protection and pathogenesis is still unclear[11]. An experimental study postulated that IgG not only fails to provide protection against this intracellular pathogen, but it actually contributes to disease progression[12], [13]. Passive administration of antileishmanial IgG antibodies resulted in larger lesions in Balb/c mice with greater amount of IL-10 production[12].…”
Section: Introductionmentioning
confidence: 99%
“…The current study found out that an increase in L. donovani parasite load resulted in high IgG antibodies. A study to quantify IgG responses in cutaneous leishmaniasis (CL) patients (23) reported high IgG antibody levels but this was found not to play any role on immunity. In the current study, reduction in IgG responses in co-infected mice which we observed may signify a lower parasite burden as compared to a single infected mice group.…”
Section: Discussionmentioning
confidence: 99%