1990
DOI: 10.1007/bf01720276
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IgG Replacement therapy for primary hypogammaglobulinaemia during pregnancy: Report of 9 pregnancies in 4 patients

Abstract: We report the cases of four pregnant women with primary hypogammaglobulinaemia, who received intramuscular, intravenous or no replacement therapy with IgG in late pregnancy, and review the literature. Intravenous replacement administered to the mother during pregnancy produces adequate serum IgG levels in the neonate, and should be the treatment of choice in this situation.

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Cited by 13 publications
(7 citation statements)
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“…Although the IgG given to pregnant women can cross the placenta and passively protect the fetus, the dose must be increased (20 to 30%) in the last trimester of pregnancy, to ensure adequate levels of antibodies to the newborn. 111,119,142 …”
Section: Mode Of Use (Administration Routes Doses and Intervals)mentioning
confidence: 99%
“…Although the IgG given to pregnant women can cross the placenta and passively protect the fetus, the dose must be increased (20 to 30%) in the last trimester of pregnancy, to ensure adequate levels of antibodies to the newborn. 111,119,142 …”
Section: Mode Of Use (Administration Routes Doses and Intervals)mentioning
confidence: 99%
“…Replacement therapy is not only necessary for the mother but also for the foetus. The foetus and the newborn synthesise little Ig and rely on active placental transport of IgG from the maternal circulation [105][106][107][108][109][110]. During pregnancy,…”
Section: Based On Various Studies a 2006 Review By Members Of The Prmentioning
confidence: 99%
“…An adequate replacement IgG therapy with increasing IgG dosages during pregnancy is essential to prevent infections and maintain well-being for women who have PAD (Sacher & King, 1988;Williams, Leen, Heppleston, & Yap, 1990). Replacement IgG therapy is also needed to provide the fetus with normal IgG and IgG-subclass concentrations for protection during birth and in the first few months of life.…”
Section: Replacement Therapy During Pregnancymentioning
confidence: 99%
“…Replacement IgG therapy is also needed to provide the fetus with normal IgG and IgG-subclass concentrations for protection during birth and in the first few months of life. Otherwise, the fetus may be born with low antibody levels and need IgG infusions postnatally (Williams et al, 1990). Despite the importance of adequate replacement IgG therapy, the effects of IgG replacement therapy to pregnant women have only been reported in a few publications during the 1980s and 1990s.…”
Section: Replacement Therapy During Pregnancymentioning
confidence: 99%
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