2016
DOI: 10.4172/2157-7560.1000322
|View full text |Cite
|
Sign up to set email alerts
|

Igg Subclasses Targeting the Flagella of Salmonella Enterica Serovar Typhimurium Can Mediate Phagocytosis and Bacterial Killing

Abstract: Invasive non-typhoidal Salmonella are a common cause of invasive disease in immunocompromised individuals and in children. Multi-drug resistance poses challenges to disease control, with a critical need for effective vaccines. Flagellin is an attractive vaccine candidate due to surface exposure and high epitope copy number, but its potential as a target for opsonophacytic antibodies is unclear.We examined the effect of targeting flagella with different classes of IgG on the interaction between Salmonella Typhi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
13
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 9 publications
(13 citation statements)
references
References 53 publications
0
13
0
Order By: Relevance
“…Although natural IgM generated by B-1 B cells in the peritoneal cavity provides an important first layer of protection against bacteria that have escaped the gut (44,45), enhanced production of IgG antibodies that bind their targets with higher specificity and can better engage immune effector pathways is required to halt bacterial invasion (46). Immunestimulating fibroblastic stromal cells that regulate B cell responses are known as follicular dendritic cells and are marked by the expression of CXCL13 and the complement receptors CD21 and CD35 (47).…”
Section: Discussionmentioning
confidence: 99%
“…Although natural IgM generated by B-1 B cells in the peritoneal cavity provides an important first layer of protection against bacteria that have escaped the gut (44,45), enhanced production of IgG antibodies that bind their targets with higher specificity and can better engage immune effector pathways is required to halt bacterial invasion (46). Immunestimulating fibroblastic stromal cells that regulate B cell responses are known as follicular dendritic cells and are marked by the expression of CXCL13 and the complement receptors CD21 and CD35 (47).…”
Section: Discussionmentioning
confidence: 99%
“…demonstrated that IgG3 was superior at mediating in-vitro OPA of S . Typhimurium, although all IgG subclasses were opsonic to varying degrees [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…In fact, protection against oral infection in immunized animals, which is IgG dependent,10 does not require the C3 component of complement, but is dependent on the function of Fc γ RI, II and III 4. Moreover, uptake and killing of IgG‐opsonized Salmonella by murine macrophages and human phagocytic cell lines can be mediated by Fc γ Rs in the absence of complement 5, 6, 7. However, poor complement activity has been inferred to be the cause of the poor antibody‐dependent bactericidal activity of mouse serum against non‐typhoidal strains of Salmonella 8.…”
Section: Introductionmentioning
confidence: 99%
“…3 The relative importance of complement and FccRs in antibody-mediated host resistance to many bacterial infections including Salmonella diseases has been controversial and difficult to determine with discrepancies between different species and experimental systems. [4][5][6][7][8][9] This has made it difficult to understand the in vivo mechanisms that underpin antibody-mediated antimicrobial functions and, moreover, has not allowed the identification of reliable and representative protocols in animal experimental systems that could be used to assist human vaccinology.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation