IgG4-related Disease Emerging after COVID-19 mRNA Vaccination

Aochi, Satsuki; Uehara, Masaaki; Yamamoto, Motohisa

doi:10.2169/internalmedicine.1125-22

Cited by 11 publications

(13 citation statements)

References 22 publications

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“…Autoimmune-related thyroid and renal case reports include that of Graves’ disease following the second dose of the Pfizer COVID-19 vaccine [ 143 ] and “rapidly progressive IgA nephropathy” following the third dose of the Moderna COVID-19 vaccine [ 144 ]. A 78-year-old woman developed IgG4-related sialadenitis and autoimmune pancreatitis following her second Pfizer COVID-19 vaccine, the authors concluded: “the use of mRNA vaccines requires more studies regarding their effects on the human immune system” [ 145 ] (p. 1550).…”

Section: Evidence Of ‘Spikeopathy’—spike Protein Pathogenicitymentioning

confidence: 99%

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Parry,

Lefringhausen,

Turni

et al. 2023

Biomedicines

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The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely.

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Section: Evidence Of ‘Spikeopathy’—spike Protein Pathogenicitymentioning

confidence: 99%

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Parry,

Lefringhausen,

Turni

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…This article reports a rare case of IgG4‐associated disease following COVID‐19 and a literature review of previous related case reports (Table 1). We found a total of six cases of IgG4 disease relevant to COVID‐19, three of which were new‐onset IgG4‐associated diseases following COVID‐19 vaccination and the remaining three following SARS‐CoV‐2 infection 2–7 . IgG4 disease does not target a specific organ and can present as pancreatitis, hepatitis, lymph node enlargement, or even tracheal injury.…”

Section: Discussionmentioning

confidence: 99%

A rare case of IgG4‐associated disease caused by COVID‐19: Case report and literature review

Zheng

Qiu

2023

Int J of Rheum Dis

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An increasing number of cases have reported that coronavirus disease 2019 (COVID‐19) can lead to immune system dysregulation and induce autoimmune diseases, but the mechanism is unclear. We treated a patient who presented with an unknown fever after infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in 2023. After excluding the possibility of infection, malignancy, and other connective tissue diseases, we considered the diagnosis of IgG4‐related disease in consideration of the patient's pathology and clinical findings. In this article, we summarize our diagnostic experience and summarize the case reports of IgG4‐related diseases associated with SARS‐CoV‐2 infections since the COVID‐19 pandemic.

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“…Recent reports have indicated that COVID-19 vaccinations using mRNA or viral vector vaccines can trigger autoimmune diseases such as sialadenitis, autoimmune hepatitis (AIH), or autoimmune pancreatitis (AIP) in selected individuals [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. In the literature, several reports have treated the correlation between autoimmune pancreatitis and COVID-19 vaccination ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Significantly Elevated CA 19-9 after COVID-19 Vaccination and Literature Review of Non-Cancerous Cases with CA 19-9 > 1000 U/mL

Ciesielka,

Jakimów,

Tekiela

et al. 2024

JCM

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Background: CA 19-9 is a commonly assessed tumor marker, considered characteristic of pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers; however, the positive predictive value of CA 19.9 is too low, and the usage of CA 19.9 as a screening tool in the healthy population remains controversial. Methods: The presented case illustrates a reversed diagnosis of highly elevated serum CA 19-9 levels in a 54-year-old female complaining of pain in the epigastric region, shortly after COVID-19 vaccination. Laboratory tests showed a significantly elevated level of the CA 19-9 marker (>12,000 U/mL, reference value: <37 U/mL) with normal pancreatic enzyme activity. The patient underwent imaging examination, which showed no abnormalities, except for increased pancreatic dimension and areas of fluid signal in the pancreas in magnetic resonance imaging (MRI), which may correspond to autoimmune pancreatitis (AIP). The patient remains asymptomatic with a recommendation for a follow-up MRI in 12 months. Results: A literature review conducted revealed multi-causal CA 19-9 increases above 1000 U/mL, including non-cancerous diseases of the lung, pancreas, liver, ovary, kidney, and others. The median concentration of CA 19-9 regardless of the cause of disease was 2810 U/mL (IQR ± 6895). The median CA 19-9 values in men and women were 3500 (IQR ± 10,050) and 2455 (IQR ± 3927), respectively, and differ significantly between the compared groups (p < 0.05). There was no difference between CA 19-9 values and the categorized cause of the increase. Conclusions: Conducting differential diagnosis, it should not be forgotten that most international guidelines recommend the use of CA 19-9 only in conjunction with pathology of pancreas in radiological imaging; however, even such a combination can point the diagnostic pathway in the wrong direction. A highly elevated CA 19-9 level, typically associated with PDAC, may be the result of benign disease including AIP related to COVID-19 vaccination.

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IgG4-related Disease Emerging after COVID-19 mRNA Vaccination

Cited by 11 publications

References 22 publications

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

A rare case of IgG4‐associated disease caused by COVID‐19: Case report and literature review

Significantly Elevated CA 19-9 after COVID-19 Vaccination and Literature Review of Non-Cancerous Cases with CA 19-9 > 1000 U/mL

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