IgG4 Related Lung Disorder -A Review

Abstract

IgG4 disorder is an autoimmune disorder. Its manifestation in the lung causes fibroinflammatory disorder. It is one of the chronic inflammatory disorders. IgG4 is the subclass of IgG. This review is analysed based on the IgG4 related disorder. Nearly 50 articles were reviewed and this study was conducted for a period of nearly 15 years.The IgG4 related disorder is a very rare disorder in the world. Moreover, It is an autoimmune disorder like Systemic lupus erythematosus. It is related to systemic disorder and chronic inflammatory disorder IgG4 varies high degree of fibrosis and it is prompted by the response of steroid therapy.It is the most common form of immunoglobulin. Ig G also known as secretory immunoglobulin.Ig G4 is a subclass of IgG comprising only 4% in gamma immunoglobulins . IgG4 does not bind to polysaccharides. Increased levels of IgG4 in serum usually found in patients suffering sclerosing pancreatitis, cholangitis and interstitial pneumonia caused by the infiltration of IgG4 positive plasma cells. IgG4 has a molecular weight of 159. IgG4 related disorder recognised as one of the rare autoimmune disorders which can affect multiple organs and cause organ failure sometimes. It involves the complement system and interacts with the antibody. Generally IgG4 related disorder is recognised as one of the most rare autoimmune disorders which can affect multiple organ failure sometimes. It involves complement system and interact with antibody. Generally, IgG4 related disorder most commonly present in in beekeper, animal laboratory workers and individuals who have undergone allergen immunotherapy possess high serum level of IgG4.it is one of the acquired Type II hypersensitivity disorder. This review mainly aims to know the reason behind the clinical lung disorder.