IgG4-Related Ophthalmic Disease. Part I

McNab, Alan A.; McKelvie, Penny

doi:10.1097/iop.0000000000000363

Cited by 80 publications

(49 citation statements)

References 60 publications

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“…With the increasing understanding of the pathology, clinical-radiological features and clinical implications of IgG4 disease over the recent years, 16,17 we believe that this specific group of disease may represent a considerable proportion of the biopsied cases in the future. A recent Japanese report described, as many as, 21.4% of their presumed 'lymphoproliferative disease' cases were of IgG4-ROD.…”

Section: Discussionmentioning

confidence: 99%

A 10-year review of orbital biopsy: the Newcastle Eye Centre Study

Ting

Pérez-López

Chew

et al. 2015

Eye

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Section: Discussionmentioning

confidence: 99%

A 10-year review of orbital biopsy: the Newcastle Eye Centre Study

Ting

Pérez-López

Chew

et al. 2015

Eye

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“…1d). Sicca symptoms are often less severe in IgG4-RD than in Sj€ ogren's syndrome and, when present, typically respond well to immunosuppressive therapy [31][32][33][34][35]. Orbital pseudotumours affect the lacrymal gland most often but can also occur in other orbital regions.…”

Section: Overview Of Clinical Manifestationsmentioning

confidence: 99%

“…Orbital pseudotumours affect the lacrymal gland most often but can also occur in other orbital regions. Extra-ocular muscle involvement (frequently termed 'orbital myositis' in the days before the recognition of IgG4-RD) can present with exophthalmos and the restriction of ocular movements [32,33] (Fig. 1e,f).…”

Section: Overview Of Clinical Manifestationsmentioning

confidence: 99%

Immunology of IgG4-related disease

Della‐Torre

Lanzillotta

Doglioni

2015

Clinical and Experimental Immunology

188

215

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SummaryImmunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition that derives its name from the characteristic finding of abundant IgG4 1 plasma cells in affected tissues, as well as the presence of elevated serum IgG4 concentrations in many patients. In contrast to fibrotic disorders, such as systemic sclerosis or idiopathic pulmonary fibrosis in which the tissues fibrosis has remained largely intractable to treatment, many IgG4-RD patients appear to have a condition in which the collagen deposition is reversible. The mechanisms underlying this peculiar feature remain unknown, but the remarkable efficacy of B cell depletion in these patients supports an important pathogenic role of B cell/T cell collaboration. In particular, aberrant T helper type 2 (Th2)/ regulatory T cells sustained by putative autoreactive B cells have been proposed to drive collagen deposition through the production of profibrotic cytokines, but definitive demonstrations of this hypothesis are lacking. Indeed, a number of unsolved questions need to be addressed in order to fully understand the pathogenesis of IgG4-RD. These include the identification of an antigenic trigger(s), the implications (if any) of IgG4 antibodies for pathophysiology and the precise immunological mechanisms leading to fibrosis. Recent investigations have also raised the possibility that innate immunity might precede adaptive immunity, thus further complicating the pathological scenario. Here, we aim to review the most recent insights on the immunology of IgG4-RD, focusing on the relative contribution of innate and adaptive immune responses to the full pathological phenotype of this fibrotic condition. Clinical, histological and therapeutic features are also addressed.

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“…The orbital tissue is also often involved, with a prevalence of 3.6-12.5% [1,[7][8][9][10]. The current diagnostic criteria of IgG4-RD include [11]: single or multiple organ swelling, either symmetrically or locally, with the formation of a mass; serum IgG4>1.35 g/L; and [12], so IgG4-RD cannot be completely excluded using this parameter [13]. Recent studies have shown that the serum IgG4 + /IgG + ratio may be more sensitive and specific in the diagnosis of early and single organ-limited development of IgG4-RD [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

A Case of IgG4-related Orbitopathy

Qin¹,

Qin²,

Wang³

et al. 2017

J Clin Exp Ophthalmol

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IgG4-related disease is an immune-mediated disorder affecting almost all major organs of the body. A 62-year-old male, who was diagnosed with an orbital tumor and a nasal-orbital communicating tumor of the left eye, underwent endoscopic endonasal removal of the orbital tumor and fenestration of the ethmoid sinus. The tumor originated in the orbital tissue and showed pathological changes associated with IgG4-positive chronic inflammation. He was diagnosed with IgG4-related orbital disease. At 4 months of follow-up after surgery, there was no recurrence.

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IgG4-Related Ophthalmic Disease. Part I

Cited by 80 publications

References 60 publications

A 10-year review of orbital biopsy: the Newcastle Eye Centre Study

A 10-year review of orbital biopsy: the Newcastle Eye Centre Study

Immunology of IgG4-related disease

A Case of IgG4-related Orbitopathy

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