IgG4-Related Sclerosing Mesenteritis

Lee, Seok Joo; Park, Cheol Keun; Yang, Woo Ick; Kim, Sangkyum

doi:10.4132/jptm.2015.12.03

Cited by 18 publications

(16 citation statements)

References 7 publications

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“…Some case reports of IgG4-related SM or possible IgG4-RD, including the present case, are summarized in Table (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). These IgG4-related SM cases occurred predominantly in older men, as is observed with IgG4-RD (23).…”

Section: Discussionmentioning

confidence: 57%

“…SM is a rare idiopathic disease characterized by chronic inflammation and fibrosis in the adipose tissue of the bowel mesentery. Recently, some case reports and case series have shown the relationship between SM and IgG4-RD (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). IgG4-RD has been newly recognized as a systemic disease and a protean condition that mimics many malignant, infectious, and inflammatory disorders (19).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some cases of SM show histologically characteristic findings of IgG4related disease (RD), such as an increased number of IgG4positive plasma cells, storiform fibrosis, and obliterative phlebitis. Therefore, these entities have been called "IgG4related mesenteritis" or "mimic of IgG4-RD" (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). While patients with IgG4-RD often have lesions in several organs, either synchronously or metachronously, there has been only one case report of IgG4-related SM with multi-organ IgG4-RD involvement (10).…”

Section: Introductionmentioning

confidence: 99%

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Sclerosing Mesenteritis Mimicking IgG4-related Disease

et al. 2020

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A 72-year-old man was followed as an outpatient at our hospital for 6 years after surgery for small cell carcinoma of left adrenal gland origin. Follow-up abdominal computed tomography showed a 6-cm mass in the left lower mesentery. The patient underwent open laparotomy. The histological diagnosis was sclerosing mesenteritis. The previous specimens of the left adrenal mass were then reexamined with a microscope, and panniculitis was found around the small cell carcinoma. Both lesions were histologically similar to IgG4related disease (RD), but they did not completely meet the diagnostic criteria of IgG4-RD clinically or histologically.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sclerosing Mesenteritis Mimicking IgG4-related Disease

et al. 2020

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“…A search of PubMed using “IgG4” and “sclerosing mesenteritis” as key words resulted in seven cases that seemed to be IgG4-related sclerosing mesenteritis [10–13, 17–19]. These seven cases and the present case are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 93%

IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report

et al. 2016

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Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. Recently, SM was reported to be closely related to IgG4-related disease (IgG4-RD). This report describes a patient with SM associated with IgG4-RD. A 77-year-old woman with a history of surgery for ectopic pregnancy and wound dehiscence presented with intestinal obstruction. Abdominal enhanced computed tomography (CT) revealed an enhanced, radially shaped, oval mass, 3 cm in diameter, with an unclear rim in the mesentery of the distal ileum, which may have involved the distal ileum. To remove the cause of bowel obstruction, the SM was resected completely and the ileum was resected partially. Histologic examination showed that the mass was composed of spindle cells arranged in a fascicular or storiform pattern; moreover, fibrous stroma was observed, with dense lymphoplasmacytic infiltration and lymphoid follicles. Immunohistochemically, numerous IgG4-positive plasma cells were observed, at a density of 253 per high-powered field, and the IgG4/IgG ratio was about 50 %. Elastica van Gieson (EVG) staining also showed obstructive phlebitis. These findings indicated IgG4-related SM. Although the accurate diagnosis of SM remains difficult without histological analysis, IgG4-RD should be included in the differential diagnosis of unknown mesenteric tumors. Identification of IgG4-RD may prevent unnecessary surgery because corticosteroids may be effective in these patients.

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“…7 IgG4-related sclerosing mesenteritis is characterised by fibrosis, lymphoplasmacytic inflammation, and obliterative thrombophlebitis with prominent IgG4positive plasma cells (PCs). 8 Microscopically, the sclerosing fibrotic stromal response associated with MTDs is often accompanied by similar adjacent foci of lymphoplasmacytic inflammation. If these features are present on core biopsy when tumour cells are not sampled, MTDs can histologically mimic sclerosing mesenteritis.…”

Section: Introductionmentioning

confidence: 99%