IgG4-Related Tubulointerstitial Nephritis Accompanied by Henoch-Schönlein Purpura

Yang, Hyung-Jeong; Choi, Soo Kyoung; Kim, Bokyoung; Yoo, Ji Myong; Koh, Eun Sil; Chang, Yoon Sik; Sungjin, Chung

doi:10.3904/kjm.2014.87.1.96

Cited by 1 publication

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“…Except for membranous nephropathy, Henoch-Schönlein purpura nephritis [ 73 - 75 ], membranoproliferative [ 76 ], and endocapillary proliferative glomerulonephritis [ 77 ] have been reported anecdotally. Cases with Henoch-Schönlein purpura nephritis had mesangial IgA deposition in addition to TIN.…”

Section: Glomerulonephritis Associated With Immunoglobulin G4-tubuloimentioning

confidence: 99%

Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers

Jeong¹,

Shin

Lim

2016

J Pathol Transl Med

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Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjögren syndrome, or anti-neutrophil cytoplasmic antibody–associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.

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