IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

Stráník, Jaroslav; Kacerovský, Marian; Souček, Ondřej; Koláčková, Martina; Musilová, Ivana; Plíšková, Lenka; Bolehovská, Radka; Boštík, Pavel; Matulova, Jana; Jacobsson, Bo; Andrýs, Ctirad

doi:10.1038/s41598-021-85473-2

Cited by 17 publications

(23 citation statements)

References 79 publications

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“…Microbial invasion of the amniotic cavity represents a condition with two clinical phenotypes: (1) intra-amniotic infection when intra-amniotic inflammation is present and (2) colonization/contamination when intra-amniotic inflammation is absent 16 , 19 , 20 . The rates of these phenotypes might differ among cohorts of women with PPROM due to differences in distribution of gestational age at rupture of membranes, race/ethnicity, and latency interval between ruptured membranes and sampling.…”

Section: Discussionmentioning

confidence: 99%

“…Aside from the "classical" scenario, called intra-amniotic infection, in which the presence of microorganisms in amniotic fluid is associated with intra-amniotic inflammation, an alternative situation, where the presence of microorganisms in the amniotic fluid is not related to intra-amniotic inflammation, has been previously reported among women with PPROM 16 , with preterm labor with intact membranes 17 , and those with a short cervix 18 . This condition is typically considered as either: (1) contamination of the amniotic fluid with skin bacteria during amniotic fluid sampling and/or during pre-analytical processing of amniotic fluid samples or (2) colonization of the amniotic cavity (colonization) with microorganisms from the lower genital tract in the absence or presence of a weak intra-amniotic inflammatory response 7 , 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of colonization of the amniotic cavity in women with preterm prelabor rupture of membranes, a retrospective study

Kacerovský

Stráník

Matulova

et al. 2022

Sci Rep

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To determine the main clinical characteristics of preterm prelabor rupture of membranes (PPROM) complicated by colonization of the amniotic cavity (microbial invasion of the amniotic cavity without intra-amniotic inflammation). A total of 302 women with PPROM were included. Transabdominal amniocentesis was performed and amniotic fluid was assessed. Based of microbial invasion of the amniotic cavity and intra-amniotic inflammation (interleukin-6 ≥ 3000 pg/mL), the women were divided into following groups: intra-amniotic infection, sterile intra-amniotic inflammation, colonization of the amniotic cavity, and negative amniotic fluid. Colonization was found in 11% (32/302) of the women. The most common bacteria identified in the amniotic fluid were Ureaplasma spp. with a lower burden than those with intra-amniotic infection (p = 0.03). The intensity of intra-amniotic inflammatory response measured by interleukin-6 was higher in women with colonization than in those with negative amniotic fluid (medians: 961 pg/mL vs. 616 pg/mL; p = 0.04). Women with colonization had higher rates of acute inflammatory placental lesions than those with negative amniotic fluid. In PPROM, colonization, caused mainly by microorganisms from the lower genital tract, might represent an early stage of microbial invasion of the amniotic cavity with a weak intra-amniotic inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of colonization of the amniotic cavity in women with preterm prelabor rupture of membranes, a retrospective study

Kacerovský

Stráník

Matulova

et al. 2022

Sci Rep

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“…Antibiotic treatment was modified if microbial invasion of the amniotic cavity occurred. Women with PTL who were positive for group B Streptococcus (GBS), determined from vaginal–rectal swabs, or had unknown GBS status, received intravenous benzylpenicillin (clindamycin, in case of penicillin allergy) during an active labor ( 50 ).…”

Section: Methodsmentioning

confidence: 99%

“…Women with PPROM with gestational age <35 weeks received corticosteroids (betamethasone) to accelerate fetal lung maturation and reduce neonatal mortality and morbidity. Women with PPROM were managed expectantly, except those with intra-amniotic infection and gestational age >28 weeks, for whom labor was induced or an elective cesarean section was performed within 72 h of admission ( 50 ).…”

Section: Methodsmentioning

confidence: 99%

Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth

Karahoda

Robles

Marushka

et al. 2021

Human Molecular Genetics

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Spontaneous preterm birth is a serious medical condition responsible for substantial perinatal morbidity and mortality. Its phenotypic characteristics, preterm labor with intact membranes (PTL) and preterm premature rupture of the membranes (PPROM), are associated with significantly increased risks of neurological and behavioral alterations in childhood and later life. Recognizing the inflammatory milieu associated with PTL and PPROM, here we examined expression signatures of placental tryptophan metabolism, an important pathway in prenatal brain development and immunotolerance. The study was performed in a well-characterized clinical cohort of healthy term pregnancies (n = 39) and 167 preterm deliveries (PTL, n = 38 and PPROM, n = 129). Within the preterm group, we then investigated potential mechanistic links between differential placental tryptophan pathway expression, preterm birth and both intra-amniotic markers (such as amniotic fluid interleukin-6) and maternal inflammatory markers (such as maternal serum C-reactive protein and white blood cell count). We show that preterm birth is associated with significant changes in placental tryptophan metabolism. Multifactorial analysis revealed similarities in expression patterns associated with multiple phenotypes of preterm delivery. Subsequent correlation computations and mediation analyses identified links between intra-amniotic and maternal inflammatory markers and placental serotonin and kynurenine pathways of tryptophan catabolism. Collectively the findings suggest that a hostile inflammatory environment associated with preterm delivery underlies the mechanisms affecting placental endocrine/transport functions and may contribute to disruption of developmental programming of the fetal brain.

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“…These biomarkers include IL-8, lipocalin-2, MIP-1α, MMP-9, and TIMP-1 ( 111 ). The protein concentrations of IgGFc-binding protein (FcγBP), which is a core mucus protein with anti-inflammatory properties, in the cervical fluid were also elevated in the presence of intra-amniotic infection in patients with PPROM (presence: 345 ng/mL vs. absence: 60 ng/mL) ( 112 ). This increase in FcγBP may help prevent massive inflammation from intra-amniotic infections.…”

Section: Potential Cervical Biomarkers Of Adverse Pregnancy Outcomesmentioning

confidence: 99%

Breaking Down the Barrier: The Role of Cervical Infection and Inflammation in Preterm Birth

Tantengco

Menon

2022

Front. Glob. Womens Health

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Approximately 40% of cases of spontaneous preterm birth (sPTB) are associated with ascending intrauterine infections. The cervix serves as a physical and immunological gatekeeper, preventing the ascent of microorganisms from the vagina to the amniotic cavity. The cervix undergoes remodeling during pregnancy. It remains firm and closed from the start until the late third trimester of pregnancy and then dilates and effaces to accommodate the passage of the fetus during delivery. Remodeling proceeds appropriately and timely to maintain the pregnancy until term delivery. However, risk factors, such as acute and chronic infection and local inflammation in the cervix, may compromise cervical integrity and result in premature remodeling, predisposing to sPTB. Previous clinical studies have established bacterial (i.e., chlamydia, gonorrhea, mycoplasma, etc.) and viral infections (i.e., herpesviruses and human papillomaviruses) as risk factors of PTB. However, the exact mechanism leading to PTB is still unknown. This review focuses on: (1) the epidemiology of cervical infections in pregnant patients; (2) cellular mechanisms that may explain the association of cervical infections to premature cervical ripening and PTB; (3) endogenous defense mechanisms of the cervix that protect the uterine cavity from infection and inflammation; and (4) potential inflammatory biomarkers associated with cervical infection that can serve as prognostic markers for premature cervical ripening and PTB. This review will provide mechanistic insights on cervical functions to assist in managing cervical infections during pregnancy.

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IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

Cited by 17 publications

References 79 publications

Clinical characteristics of colonization of the amniotic cavity in women with preterm prelabor rupture of membranes, a retrospective study

Clinical characteristics of colonization of the amniotic cavity in women with preterm prelabor rupture of membranes, a retrospective study

Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth

Breaking Down the Barrier: The Role of Cervical Infection and Inflammation in Preterm Birth

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