IgM antibodies to P1 cytoadhesin of mycoplasma pneumoniae are part of the natural antibody repertoire expressed early in life

Ben-Aissa-Fennira, F; A, Ben Ammar-el Gaaied; Bouguerra, A; Dellagi, Koussay

doi:10.1016/s0165-2478(98)00053-4

Cited by 13 publications

(5 citation statements)

References 8 publications

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“…Large individual variation in ecologically-significant levels of NAbs also have been reported in humans, mice, birds, and fish (Ben-Aissa-Fennira et al, 1998; Sinyakov et al, 2002; Parmentier et al, 2004; Kachamakova et al, 2006). Due to the inherent polyspecificity of NAbs, we hypothesise that high NAb levels to OVA in tortoises may indicate high levels of NAbs to actual pathogens and greater resistance to pathogenic disease (Gonzalez et al, 1988; Flajnik and Rumfelt, 2000; Baumgarth et al, 2005).…”

Section: Discussionmentioning

confidence: 92%

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

et al. 2012

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SummaryVertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans.

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Section: Discussionmentioning

confidence: 92%

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

et al. 2012

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“…19 However, most of the autoantibody biomarker studies explicitly exploit IgG immunoglobulin-isotype autoantibodies that postdate the first-line immune responses. IgM antibodies, in contrast, are considered to be the first immunoglobulin isotype that emerges during a humoral immune response after an initial immunological challenge and have been implicated not only in the early recognition of external invading pathogens, such as bacteria and viruses, [20][21][22][23] but also in the recognition and elimination of precancerous and cancerous lesions. [24][25][26] Consequently, exploring IgM autoantibodies as early cancer detection tools is purposefully more relevant and promising.…”

Section: Introductionmentioning

confidence: 99%

IgM and IgA augmented autoantibody signatures improve early‐stage detection of colorectal cancer prior to nodal and distant spread

et al. 2021

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Objectives Tumor‐associated autoantibodies (AAbs) in individuals with cancer can precede clinical diagnosis by several months to years. The objective of this study was to determine whether the primary immune response in form of IgM and gut mucosa‐associated IgA can aid IgG AAbs in the detection of early‐stage colorectal cancer (CRC). Methods We developed a novel protein array comprising 492 antigens seropositive in CRC. The array was used to profile IgG, IgM and IgA antibody signatures in 99 CRC patients and 99 sex‐ and age‐matched non‐cancer controls. A receiver operating curve (ROC), Kaplan–Meier survival analysis and univariate and multivariate Cox regression analyses were conducted. Results We identified a panel of 16 multi‐isotype AAbs with a cumulative sensitivity of 91% and specificity of 74% (AUC 0.90, 95% CI: 0.850–0.940) across all CRC stages. IgM and IgG isotypes were conversely associated with disease stage with IgM contributing significantly to improved stage I and II sensitivity of 96% at 78% specificity (AUC 0.928, 95% CI: 0.884–0.973). A single identified IgA AAb reached an overall sensitivity of 5% at 99% specificity (AUC 0.520, 95% CI: 0.440–0.601) balanced across all CRC stages. Kaplan–Meier analysis revealed that se33‐1 (ZNF638) IgG AAbs were associated with reduced 5‐year overall survival (log‐rank test, P = 0.012), whereas cumulative IgM isotype signatures were associated with improved 5‐year overall survival (log‐rank test, P = 0.024). Conclusion IgM AAbs are associated with early‐stage colorectal cancer. Combining IgG, IgM and IgA AAbs is a novel strategy to improve early diagnosis of cancers.

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“…They are responsible for the early detection and elimination of modified, secreted, self-cells and-structures, like DNA, RNA, filaments, oxidized molecules and transformed cells. In addition they are involved in the detection and elimination of foreign particles, like bacteria, fungi and viruses [31][32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

PAM-1, a natural human IgM antibody as new tool for detection of breast and prostate precursors

Brändlein

Eck

Ströbel

et al. 2005

HAB

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Early detection and differential analysis of premalignant lesions are very important for both prognosis and therapy of cancer patients. A good source of diagnostic tools is the natural antibody pool of humans. Tumor-specific antibodies can be established by using hybridoma technology. The fully human germline-coded monoclonal IgM antibody PAM-1 was isolated from a patient with a stomach carcinoma. PAM-1 reacts with a post-transcriptionally modified isoform of membrane receptor CFR-1 which is overexpressed on almost all epithelial cancers of all types and origins. The expression of CFR-1/PAM-1 on precancerous stages of breast and prostate cancer was analyzed by immunohistochemistry and compared with normal breast and prostate tissue as well as adenocarcinomas of both. In addition FACS analysis was performed to detect receptor expression on benign and malign prostate cells. 73 different tissue samples of prostate and breast precancerous stages and prostate and breast carcinomas were analysed for CFR-1/PAM-1 expression immunohistochemically. The CFR-1/PAM-1 receptor was expressed on nearly all precancerous stages and carcinomas while normal breast and prostate tissue showed negative results. These results were confirmed by FACS analysis showing a CFR-1/PAM-1 expression only on prostate carcinoma cells but not on benign prostate hyperplasia cells. The unique expression of this new CFR-1/PAM-1 receptor makes the PAM-1 antibody an ideal diagnostic and even therapeutic tool for precancerous and cancerous epithelial lesions of the breast and the prostate.

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IgM antibodies to P1 cytoadhesin of mycoplasma pneumoniae are part of the natural antibody repertoire expressed early in life

Cited by 13 publications

References 8 publications

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

IgM and IgA augmented autoantibody signatures improve early‐stage detection of colorectal cancer prior to nodal and distant spread

PAM-1, a natural human IgM antibody as new tool for detection of breast and prostate precursors

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