Ignatia in the treatment of oral lichen planus

Mousavi, Fahimeh; Sherafati, Safa; Mojaver, Yalda Nozad

doi:10.1016/j.homp.2008.11.007

Cited by 37 publications

(30 citation statements)

References 8 publications

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“…There was no evidence of difference in mean pain score after treatment between active intervention & placebo in three trials [18,19,30]. A statistically significant reduction in mean pain score favouring the active intervention was seen in the remaining nine trials [3,17,21,[24][25][26]32,33,37].…”

Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 93%

“…In the other studies, both patients and outcome assessors were unblind or no clear information was provided. [35] had more than 20% drop-outs and an another study [25] does not specify about drop-outs.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 96%

“…Other treatments included: aloe vera in three trials [21,30,31], hyaluronic acid [26], curcuminoids as adjunctive treatment to prednisone [18], Bacillus Calmette-Guerin polysaccharide nucleic acid [28], topical retinoic acid [6], topical thalidomide [29], lycopene [32], topical isotretinoin [12], ignatia [25] & MuGard [37].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Twelve trials compared an active intervention with placebo: cyclosporine [3], clobetasol & miconazole [19], curcuminoids as an adjunct to prednisone [18], pimecrolimus [17,24,33], aloe vera [21,30], hyaluronic acid [26], ignatia [25], lycopene [32] & MuGard [37]. There was no evidence of difference in mean pain score after treatment between active intervention & placebo in three trials [18,19,30].…”

Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 99%

“…Few studies [3,17,21,[24][25][26]33,37] found a statistically significant difference in clinical improvement favouring their respective active interventions when compared to placebo. No statistically significant clinical improvement in the intervention groups when compared to placebo was noted by few other studies [18,19,30].…”

Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 99%

See 4 more Smart Citations

Medical Management of Oral Lichen Planus: A Systematic Review

Suresh

Krunal²,

Desai³

et al. 2016

JCDR

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Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 93%

Section: Risk Of Bias Within Studiesmentioning

confidence: 96%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 99%

Section: Effects Of Interventions Active Intervention Vs Placebomentioning

confidence: 99%

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Medical Management of Oral Lichen Planus: A Systematic Review

Suresh

Krunal²,

Desai³

et al. 2016

JCDR

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Interventions for treating oral lichen planus

Thongprasom

Carrozzo

Furness

et al. 2011

Cochrane Database of Systematic Reviews

140

131

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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Ignatia in the treatment of oral lichen planus

Abstract: Our results suggest that Ignatia has a beneficial effect in treatment of OLP in selected patients.

Cited by 37 publications

References 8 publications

Medical Management of Oral Lichen Planus: A Systematic Review

Medical Management of Oral Lichen Planus: A Systematic Review

Interventions for treating oral lichen planus

Interventions for treating oral lichen planus: corticosteroid therapies

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