IGSF8 is a potential target for the treatment of gliomas

Ren, Jiaxing; Huang, Ping; Wang, Fei

doi:10.1016/j.asjsur.2024.02.118

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2024

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“…This molecule is primarily expressed on cell membranes and exerts its effects through unique transmembrane interactions (125-127). Recent studies have unveiled that IGSF8 is highly expressed in several cancer types, where it significantly modulates the immune microenvironment by interacting with key immune cells like natural killer (NK) cells and dendritic cells (DCs) (31,125,128).…”

Section: Igsf8mentioning

confidence: 99%

From mechanism to therapy: the journey of CD24 in cancer

Zhao,

Wu,

et al. 2024

Front. Immunol.

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CD24 is a glycosylphosphatidylinositol-anchored protein that is expressed in a wide range of tissues and cell types. It is involved in a variety of physiological and pathological processes, including cell adhesion, migration, differentiation, and apoptosis. Additionally, CD24 has been studied extensively in the context of cancer, where it has been found to play a role in tumor growth, invasion, and metastasis. In recent years, there has been growing interest in CD24 as a potential therapeutic target for cancer treatment. This review summarizes the current knowledge of CD24, including its structure, function, and its role in cancer. Finally, we provide insights into potential clinical application of CD24 and discuss possible approaches for the development of targeted cancer therapies.

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Section: Igsf8mentioning

confidence: 99%