Iguape: A Newly Recognized Flavivirus from São Paulo State, Brazil

Coimbra, Terezinha Lisieux Moraes; Nassar, E.S.; Nagamori, Adélia H; Ferreira, Ítalo Eustáquio; Pereira, Luiz Eloy; Rocco, Iray Maria; Ueda-Ito, M.; Romano, N

doi:10.1159/000150333

Cited by 23 publications

(19 citation statements)

References 6 publications

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“…IGUV is in a clade together with Kokobera virus (Figure 1A). It was isolated from a sentinel forest mouse in Brazil in 1979 and is suspected to infect mice, marsupials and birds (Coimbra et al, 1993). SPOV is a mosquito-borne flavivirus closely related to ZIKV.…”

Section: Resultsmentioning

confidence: 99%

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Grant

Ponia

Tripathi

et al. 2016

Cell Host & Microbe

694

770

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Summary The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses examined could suppress IFN signaling, but through different mechanisms. ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans but not mice, which may explain the requirement for IFN-deficiency to observe ZIKV-induced disease in mice. The mechanism of ZIKV NS5 resembles dengue virus (DENV) NS5 and not its closer relative, Spondweni virus (SPOV). However, unlike DENV, ZIKV did not require the E3 ubiquitin ligase UBR4 to induce STAT2 degradation. Hence, flavivirus NS5 proteins exhibit a remarkable functional convergence in IFN antagonism, albeit by virus-specific mechanisms.

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Section: Resultsmentioning

confidence: 99%

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Grant

Ponia

Tripathi

et al. 2016

Cell Host & Microbe

694

770

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“…Despite the geographic dispersal of BSQV, which is mainly located in the Caribbean and Central America (Gubler et al 2007), the WNV seropositive samples were also submitted to PRNT 90 for BSQV to minimise potential high-titered cross reaction antibodies. However, considering that IGUV was only isolated from sentinel mice in the Southeastern Brazil (Coimbra et al 1993) and that serosurveys suggest infrequent occurrence of overt infection, in the present study IGUV was not included in the PRNT methods.…”

Section: Discussionmentioning

confidence: 99%

Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal

Pauvolid‐Corrêa

Morales

Levis

et al. 2011

Mem. Inst. Oswaldo Cruz

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The Pantanal is a tropical, seasonal wetland of approximately 140,000 km 2 that is fed by tributaries of the upper Paraguay River in the centre of South America, which covers mainly Brazilian but also Paraguayan and Bolivian territories and is classified as one of the largest freshwater wetland ecosystems in the world (Alho 2005). The Brazilian Pantanal, which represents 85% of the total Pantanal area, is located within the states of Mato Grosso do Sul and Mato Grosso in Central-West Brazil, which are recognised as South and North Pantanal, respectively (Alho et al. 1988). This region is ecologically classified into sub-regions according to vegetation, flooding and physiography (Silva & Abdon 1988). The Nhecolândia sub-region that is situated in South Pantanal is one of the largest, comprising approximately one fifth of the total area, and is characterised by hundreds of shallow lakes that display varying degrees of salinity and coalescence with the system during floods (Adámoli 1982).Recent studies have demonstrated that some crocodilian species may be infected by WNV (Steinman et al. 2003, Jacobson et al. 2005 and that Alligator mississippiensis may also have a viremic load that affords the infection of blood-feeding Culicidae vectors, which suggests that in areas with high population densities of these alligators, juvenile individuals could play an important role in WNV transmission (Klenk et al. 2004). Taking these data into account, the unsuccessful efforts to detect WNV circulation in the avian hosts in Brazil and the widespread, high prevalence of the Crocodilia species, Caiman crocodilus yacare, in the Brazilian Pantanal (Campos et al. 2005), our strategy was to investigate the WNV circulation in the potential vectors, dead-end hosts and natural secondary amplifying hosts through the collection and testing of mosquitoes and serum samples of horses and wild caimans from the Nhecolândia sub-region. No morbidity was observed during the sampling period and only apparently healthy horses and caimans were sampled in the present study. MATERiALS AND METHoDSStudy area -In February 2009, mosquitoes and blood samples from horses and wild caimans were collected in six different cattle ranches of the Nhecolândia sub-region (18º20' 19º40'S and 57º14' 55º00'W) during the rainy season. Considering the free circulation of mosquitoes, horses and wild caimans in large ranches, sample collections for the study were undertaken in a 700-square-kilometre (70,000 ha) area (Figure). The collections for this study were authorised by the Brazilian Institute of Environment and Natural Resources (license IBAMA 18363-1/2009).Samples collections -Adult mosquitoes were captured at sites that were randomly selected using CDC automatic light traps and manual aspirators while landing to blood-feed on horses and research team members as routinely reported. Living mosquito specimens were transported to a field laboratory where they were immobilised by chilling and the species were identified through direct observation of the morphological ...

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“…Thirteen flaviviruses have been reported in Brazil, listed here in chronological order of discovery: YFV, ILHV, BSQV, SLEV, ROCV, CPCV, Dengue virus 1 (DENV-1) and Dengue virus 4 (DENV-4), Dengue virus 2 (DENV-2), Iguape virus (IGUV), Naranjal-like virus (NJLV), Dengue virus 3 (DENV-3) and Culex flavivirus (CXFV) [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]. In 2009, serological evidence of West Nile virus (WNV) infection in Brazilian horses, was collected for the first time, in the Pantanal wetland region of Mato Grosso do Sul state (MS) [21].…”

Section: Introductionmentioning

confidence: 99%

Serological Evidence of Widespread Circulation of West Nile Virus and Other Flaviviruses in Equines of the Pantanal, Brazil

et al. 2014

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A recent study reported neutralizing antibodies to West Nile virus (WNV) in horses from four ranches of southern Pantanal. To extend that study, a serosurvey for WNV and 11 Brazilian flaviviruses was conducted with 760 equines, 238 sheep and 61 caimans from 17 local cattle ranches. Among the tested equines, 32 were collected from a ranch where a neurologic disorder outbreak had been recently reported. The sera were initially screened by using a blocking ELISA and then titrated by 90% plaque-reduction neutralization test (PRNT90) for 12 flaviviruses. Employing the criterion of 4-fold greater titer, 78 (10.3%) equines were seropositive for Ilheus virus, 59 (7.8%) for Saint Louis encephalitis virus, 24 (3.2%) for WNV, two (0.3%) for Cacipacore virus and one (0.1%) for Rocio virus. No serological evidence was found linking the neurological disease that affected local equines to WNV. All caimans and sheep were negative by blocking ELISA for flaviviruses. There were no seropositive equines for Bussuquara, Iguape, Yellow fever and all four Dengue virus serotypes. The detection of WNV-seropositive equines in ten ranches and ILHV and SLEV-seropositive equines in fourteen ranches of two different sub-regions of Pantanal is strong evidence of widespread circulation of these flaviviruses in the region.

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Iguape: A Newly Recognized Flavivirus from São Paulo State, Brazil

Cited by 23 publications

References 6 publications

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal

Serological Evidence of Widespread Circulation of West Nile Virus and Other Flaviviruses in Equines of the Pantanal, Brazil

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