II Sifu PCR to Cells and to Wax Sections: An Alternative to In Situ Hybridjzation for the Detection of Low Copies of Human Papillomavirus and Cytomegalovirus DNA

Mougin, Christiane; Didier, J.M.; Bettinger, Dominique; Madoz, Laurence; Coumes-Marquet, S.; Lab, M.

doi:10.1385/0-89603-395-3:77

Cited by 5 publications

(1 citation statement)

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“…Polymerase chain reaction on the biopsy specimen holds potential for increasing yield but is still considered a research tool. 8,9 Ganciclovir is the most commonly used agent in CMV treatment. Because of limited absorption, the oral form of ganciclovir should not be used for treating gastrointestinal CMV infection.…”

Section: Bowel Typical Histologic Features Of CMV Infecion Include Ementioning

confidence: 99%

Cytomegalovirus Ischemic Colitis: A Near-Fatal Presentation of HIV Infection

Lin¹,

Behling²,

Garvie³

2004

aids patient care stds

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Cytomegalovirus infection occurs in immunocompromised patients.We present a 45-year-old male with no prior medical history who presented to the hospital with weight loss and nonbloody diarrhea. During hospitalization, he developed severe hematochezia and hypotension. Colonoscopy revealed dusky, friable mucosa. The patient arrested and was resuscitated. Specimen from emergent colectomy showed ischemic changes secondary to cytomegalovirus infection of endothelium and small-vessel thrombosis. An HIV test was subsequently positive with CD4 count of 2 per microliter. The patient was treated with antiretroviral therapy and ganciclovir. He survived postoperative infections and was eventually discharged. In summary, this case of near-fatal cytomegalovirus colitis represents an unusual presentation of undiagnosed HIV infection. Cytomegalovirus infection should be included in the differential diagnosis of immunocompromised patients with gastrointestinal symptoms. Hematochezia may be from intestinal ulceration or severe ischemic damage. Antiretroviral therapy and ganciclovir or foscarnet should be initiated promptly. Surgery is indicated in life-threatening hemorrhage or obvious bowel necrosis.

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Section: Bowel Typical Histologic Features Of CMV Infecion Include Ementioning

confidence: 99%