III-10, a newly synthesized flavonoid, induces cell apoptosis with the involvement of reactive oxygen species-mitochondria pathway in human hepatocellular carcinoma cells

Dai, Qinsheng; Yin, Qian; Zhao, Yikai; Guo, Rongbo; Li, Zhiyu; Ma, Shengming; Lu, Na

doi:10.1016/j.ejphar.2015.06.057

Cited by 12 publications

(6 citation statements)

References 33 publications

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“…Nano-Cur improves oxidative stress markers in vitro in rat SCs culture ROS may attack intracellular biological macromolecules, including nuclear acids, lipids and proteins, finally inducing mitochondrial dysfunction and cell apoptosis [40]. ROS are released from mitochondria, and their excess can disrupt the mitochondrial membrane potential (ΔΨm) [41].…”

Section: Resultsmentioning

confidence: 99%

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Caillaud

Msheik

Ndong-Ntoutoume

et al. 2020

Free Radical Biology and Medicine

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Section: Resultsmentioning

confidence: 99%

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Caillaud

Msheik

Ndong-Ntoutoume

et al. 2020

Free Radical Biology and Medicine

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“…To further elucidate the 7-KC mode of action in LMSCs, the status of caspase activation was determined using Z-VAD-FMK, a cell-permeant pan-caspase inhibitor [64]. We have demonstrated that Z-VAD-FMK only partially reverses 7-KC-promoting cell death at high concentrations.…”

Section: Discussionmentioning

confidence: 99%

7-Ketocholesterol Promotes Oxiapoptophagy in Bone Marrow Mesenchymal Stem Cell from Patients with Acute Myeloid Leukemia

Paz

Levy

Oliveira

et al. 2019

Cells

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7-Ketocholesterol (7-KC) is a cholesterol oxidation product with several biological functions. 7-KC has the capacity to cause cell death depending on the concentration and specific cell type. Mesenchymal stem cells (MSCs) are multipotent cells with the ability to differentiate into various types of cells, such as osteoblasts and adipocytes, among others. MSCs contribute to the development of a suitable niche for hematopoietic stem cells, and are involved in the development of diseases, such as leukemia, to a yet unknown extent. Here, we describe the effect of 7-KC on the death of bone marrow MSCs from patients with acute myeloid leukemia (LMSCs). LMSCs were less susceptible to the death-promoting effect of 7-KC than other cell types. 7-KC exposure triggered the extrinsic pathway of apoptosis with an increase in activated caspase-8 and caspase-3 activity. Mechanisms other than caspase-dependent pathways were involved. 7-KC increased ROS generation by LMSCs, which was related to decreased cell viability. 7-KC also led to disruption of the cytoskeleton of LMSCs, increased the number of cells in S phase, and decreased the number of cells in the G1/S transition. Autophagosome accumulation was also observed. 7-KC downregulated the SHh protein in LMSCs but did not change the expression of SMO. In conclusion, oxiapoptophagy (OXIdative stress + APOPTOsis + autophagy) seems to be activated by 7-KC in LMSCs. More studies are needed to better understand the role of 7-KC in the death of LMSCs and the possible effects on the SHh pathway.

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“…A 10 μL aliquot of the test samples was added to cells and cultured at 37 °C for 3 days at 5% CO 2 . The colorimetric MTT assay was referred to as Dai [ 43 ]. The A549, Bel7402, and HepG2 cells were treated with MTT solution (a final concentration of 0.5 mg/mL in DMEM) for 4 h at 37 °C in a 96-well plate, the supernatant was carefully removed, and DMSO (150 μL) was added to each well to dissolve the precipitate.…”

Section: Methodsmentioning

confidence: 99%

Beneficial Phytochemicals with Anti-Tumor Potential Revealed through Metabolic Profiling of New Red Pigmented Lettuces (Lactuca sativa L.)

Qin

Zhang

Han

et al. 2018

IJMS

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The present study aimed to compare polyphenols among red lettuce cultivars and identify suitable cultivars for the development and utilization of healthy vegetables. Polyphenols, mineral elements, and antioxidant activity were analyzed in the leaves of six red pigmented lettuce (Lactuca sativa L.) cultivars; thereafter, we assessed the anti-tumor effects of cultivar B-2, which displayed the highest antioxidant activity. Quadrupole–Orbitrap mass spectrometry analysis revealed four classes of polyphenols in these cultivars. The composition and contents of these metabolites varied significantly among cultivars and primarily depended on leaf color. The B-2 cultivar had the highest antioxidant potential than others because it contained the highest levels of polyphenols, especially anthocyanin, flavone, and phenolic acid; furthermore, this cultivar displayed anti-tumor effects against the human lung adenocarcinoma cell line A549, human hepatoma cell line Bel7402, human cancer colorectal adenoma cell line HCT-8, and HT-29 human colon cancer cell line. Hence, the new red-leaf lettuce cultivar B-2 has a distinct metabolite profile, with high potential for development and utilization of natural phytochemical and mineral resources in lettuces and can be used as a nutrient-dense food product.

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III-10, a newly synthesized flavonoid, induces cell apoptosis with the involvement of reactive oxygen species-mitochondria pathway in human hepatocellular carcinoma cells

Cited by 12 publications

References 33 publications

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

7-Ketocholesterol Promotes Oxiapoptophagy in Bone Marrow Mesenchymal Stem Cell from Patients with Acute Myeloid Leukemia

Beneficial Phytochemicals with Anti-Tumor Potential Revealed through Metabolic Profiling of New Red Pigmented Lettuces (Lactuca sativa L.)

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