This study adopts a descriptive survey research design with a quantitative approach to examine the impact of malaria prevalence on infant mortality in selected local government areas across all three senatorial districts of Kogi State, Nigeria. The study covers Lokoja and Ajaokuta LGAs from the Central district, Omala, Igalamela-Odolu, Ibaji, and Bassa LGAs from the East district, and Kabba/Bunu LGA from the West district. These local government areas were selected based on their proneness to flooding and the presence of rivers nearby. Utilising a randomly selected population, data was collected through structured questionnaires and analysed using Binary Logistic Regression. While the results indicate a positive relationship between malaria prevalence and infant mortality, the statistical significance is not established. The study underscores the financial and economic burden associated with malaria treatment, transportation, and prevention, suggesting the need for a comprehensive approach to public health challenges. Policy recommendations include improving healthcare accessibility, promoting awareness campaigns, implementing targeted subsidies for antimalarial medications, and enhancing public transportation services to facilitate easier access to medical facilities.