Iii. The Diffusible Calcium of the Blood Serum in Allergic Diseases

Greenberg, David M.

doi:10.1001/archinte.1930.00140130075006

Cited by 6 publications

(1 citation statement)

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“…Studies of circadian variation in total plasma calcium concentration are conflicting. In fasting subjects some have reported that no fluctuations occur Gunther, 1930 andPhilpot, 1958), while others have reported changes of 2 or 3 mg per 100 ml during a 24-hour period (Nicolaysen, 1932). Similarly in subjects on a normal diet it has been reported that there are no appreciable variations (Watchorn, 1929;Carruthers, Copp, and McIntosh, 1964), while others have reported marked fluctuations (Philpot, 1958;Chaptal, Jean, Guillamot, and Morel, 1962).…”

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The effect of diurnal variation on total plasma calcium concentration in normal subjects

Wills

1970

J Clin Pathol

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SYNOPSIS In 12 normal subjects plasma calcium and phosphorus concentrations were estimated during a normal working day. In the individual subjects fluctuations from the fasting values occurred during the period of study, but at no time during that period did the mean values differ significantly from the fasting plasma calcium or phosphorus concentrations. In three of the subjects the study was repeated while fasting durin-a normal working day. In these subjects the fluctuations in both plasma calcium and phosphorus concentrations were less than during a normal day while taking meals, and there was evidence of a diurnal variation in the plasma phosphorus concentration.The alternation of daily activity and nocturnal sleep is associated with a circadian rhythm in the concentration of some blood constituents and in the renal output of water and electrolytes (Mills, 1966). Studies of circadian variation in total plasma calcium concentration are conflicting. In fasting subjects some have reported that no fluctuations occur Gunther, 1930 andPhilpot, 1958), while others have reported changes of 2 or 3 mg per 100 ml during a 24-hour period (Nicolaysen, 1932). Similarly in subjects on a normal diet it has been reported that there are no appreciable variations (Watchorn, 1929;Carruthers, Copp, and McIntosh, 1964), while others have reported marked fluctuations (Philpot, 1958;Chaptal, Jean, Guillamot, and Morel, 1962). Farquharson and Tibbetts (1931), in a study of two healthy adults during ordinary work, found that the plasma calcium concentration was constant in one and varied in the other.In view of these conflicting reports, and as the estimation of total plasma calcium concentration is, at present, one of the most valuable indices of disorders ofcalcium homeostasis, the study reported here was undertaken in an attempt to define the effect of diurnal variation on total plasma calcium concentration in normal subjects.Received for publication 4 May 1970. Subjects StudiedNine males and three females were studied. All were healthy members of the laboratory staff and their ages ranged from 22 to 50 years. During the day of study they followed their normal daily work routine and received a standard diet. The diet was prepared to give a normal content of fat, carbohydrate, and protein with a fixed calcium intake of 1,100 mg/day; this approximately equalled their usual diet and the normal daily adult intake (National Food Survey, 1963). The distribution of the calcium intake (mainly as milk) through the study day was 260 mg at 0915, 140 mg at 1030, 245 mg at 1230, 220 mg at 1530, and 235 mg at 1830 hours. Routine of Specimen CollectionAfter an overnight fast blood was collected at 0900 hours and thereafter at approximately three-hourly intervals with a final blood specimen at 2000 hours in nine of the subjects. In the other three subjects blood specimens were col-

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