2023
DOI: 10.1111/cpr.13535
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IKK/NF‐κB and ROS signal axes are involved in Tenacissoside H mediated inhibitory effects on LPS‐induced inflammatory osteolysis

Abstract: Periodontal disease and arthroplasty prosthesis loosening and destabilization are both associated with osteolysis, which is predominantly caused by abnormal bone resorption triggered by pro‐inflammatory cytokines. Osteoclasts (OCs) are critical players in the process. Concerns regarding the long‐term efficacy and side effects of current frontline therapies, however, remain. Alternative therapies are still required. The aim of this work was to investigate the involvement of Tenacissoside H (TDH) in RANKL‐mediat… Show more

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Cited by 6 publications
(3 citation statements)
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“…Lipopolysaccharide (LPS) is made up of polysaccharides and lipids and forms an integral part of the cell wall in Gram-negative bacteria, it can act as an inducer of inflammation, thereby triggering the release of inflammatory cytokines ( Xie et al, 2024 ). LPS can increase renal tubular injury and cell apoptosis, induce mitochondrial function and dynamic disorders ( Jian et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…Lipopolysaccharide (LPS) is made up of polysaccharides and lipids and forms an integral part of the cell wall in Gram-negative bacteria, it can act as an inducer of inflammation, thereby triggering the release of inflammatory cytokines ( Xie et al, 2024 ). LPS can increase renal tubular injury and cell apoptosis, induce mitochondrial function and dynamic disorders ( Jian et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…Lipopolysaccharide (LPS) is made up of polysaccharides and lipids and forms an integral part of the cell wall in Gram-negative bacteria, it can act as an inducer of inflammation, thereby triggering the release of inflammatory cytokines (Xie et al, 2024). LPS can increase renal tubular injury and cell apoptosis, induce mitochondrial function and dynamic disorders (Jian et al, 2023).…”
Section: Introductionmentioning
confidence: 99%
“…Lipopolysaccharide (LPS) is made up of polysaccharides and lipids and forms an integral part of the cell wall in Gram-negative bacteria, it can act as an inducer of inflammation, thereby triggering the release of inflammatory cytokines (Xie et al, 2024). LPS can increase renal tubular injury and cell apoptosis, induce mitochondrial function and dynamic disorders (Jian et al, 2023).…”
Section: Introductionmentioning
confidence: 99%