2023
DOI: 10.3389/fcell.2022.1083743
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IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy

Abstract: Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion of inflammatory components, known as senescence-associated secretory phenotype (SASP). However, recent reports demonstrated that anti-cancer therapy itself can stimulate a senescence response in tumor cells, the so-called therapy-induced senescence (TIS), whic… Show more

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Cited by 3 publications
(1 citation statement)
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“…Among the cancer hallmarks suggested for the third edition in 2022, four new ones were added, including senescent cells [ 17 ]. Targeting the activation or inhibition of cellular senescence is beneficial for tumor immunotherapy [ 18 ]. Although several lines of evidence indicate that young adults with cancers demonstrate unique histological and survival heterogeneity, their biology is incompletely understood [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Among the cancer hallmarks suggested for the third edition in 2022, four new ones were added, including senescent cells [ 17 ]. Targeting the activation or inhibition of cellular senescence is beneficial for tumor immunotherapy [ 18 ]. Although several lines of evidence indicate that young adults with cancers demonstrate unique histological and survival heterogeneity, their biology is incompletely understood [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%