1993
DOI: 10.4049/jimmunol.150.12.5625
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IL-1 and transforming growth factor-beta inhibit platelet-derived growth factor-AA binding to osteoblastic cells by reducing platelet-derived growth factor-alpha receptor expression.

Abstract: Platelet-derived growth factor (PDGF) is thought to play a significant role in bone repair and regeneration. We previously demonstrated that PDGF-AA-induced chemotaxis and proliferation can be modulated by IL-1. We now report that IL-1 and transforming growth factor-beta (TGF-beta) significantly decrease the number of PDGF-AA binding sites in both normal and tumor-derived human osteoblastic cells, whereas PDGF-BB binding is minimally affected. The affinity of PDGF-AA binding remains unchanged in the presence o… Show more

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“…Fibrin adhesives also began to be related to a greater ability to repair surgical wounds after work performed where these adhesives or adhesives were obtained from the patient's peripheral blood collection before surgery. As an alternative for this fibrin glue, the use of platelet gel was suggested for use in oral and buccomaxillofacial surgery with the advantages of greater safety against infections and greater support for wound healing, due to the presence of a greater number of factors of Growth [33].…”
Section: Mednext Journal Of Medical and Health Sciencesmentioning
confidence: 99%
“…Fibrin adhesives also began to be related to a greater ability to repair surgical wounds after work performed where these adhesives or adhesives were obtained from the patient's peripheral blood collection before surgery. As an alternative for this fibrin glue, the use of platelet gel was suggested for use in oral and buccomaxillofacial surgery with the advantages of greater safety against infections and greater support for wound healing, due to the presence of a greater number of factors of Growth [33].…”
Section: Mednext Journal Of Medical and Health Sciencesmentioning
confidence: 99%