IL-1αand IL-1βLevels in Blood Serum and Saliva of Menopausal Women

Rahnama, Mansur; Jastrzębska, Izabela; Jamrogiewicz, Rafał; Kocki, Janusz

doi:10.3109/07435800.2012.713425

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…Under such conditions, salivary inflammation increases due to higher local production of inflammatory factors and possibly an increased infiltration from blood (Bosch, 2014). Several studies have reported substantially higher levels of inflammatory markers in saliva than in blood (Khan, 2012; Miller et al, 2010; Rahnama et al, 2013), further supporting the notion that salivary cytokines are being produced by local tissues in lieu of (or in addition) to their infiltrating the mouth from the periphery (i.e., from blood). Importantly, a vast majority (>80%) of adults in the United States exhibit gingivitis in one or more teeth, and almost 50% of individuals over age 50 present with some level of periodontal disease (Albandar, 2002).…”

Section: Discussionmentioning

confidence: 69%

“…The studies that have focused on correlations between salivary and blood-based inflammation have been conducted with static, baseline levels (i.e., not in response to stress) (Rahnama et al, 2013; Williamson et al, 2012). Salivary inflammatory cytokines may perhaps relate better to blood-based cytokines in the context of stress responses, and/or if examined on a lagged time basis from systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Salivary markers of inflammation in response to acute stress

Slavish

Graham‐Engeland

Smyth

2015

Brain, Behavior, and Immunity

216

201

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There is burgeoning interest in the ability to detect inflammatory markers in response to stress within naturally occurring social contexts and/or across multiple time points per day within individuals. Salivary collection is a less invasive process than current methods of blood collection and enables intensive naturalistic methodologies, such as those involving extensive repeated measures per day over time. Yet the reliability and validity of saliva-based to blood-based inflammatory biomarkers in response to stress remains unclear. We review and synthesize the published studies that have examined salivary markers of inflammation following exposure to an acute laboratory stressor. Results from each study are reviewed by analyte (IL-1β, TNF-α, IL-6, IL-2, IL-4, IL-10, IL-12, CRP) and stress type (social-cognitive and exercise-physical), after which methodological issues and limitations are addressed. Although the literature is limited, several inflammatory markers (including IL-1β, TNF-α, and IL-6) have been reliably determined from saliva and have increased significantly in response to stress across multiple studies, with effect sizes ranging from very small to very large. Although CRP from saliva has been associated with CRP in circulating blood more consistently than other biomarkers have been associated with their counterparts in blood, evidence demonstrating it reliably responds to acute stress is absent. Although the current literature is presently too limited to allow broad assertion that inflammatory biomarkers determined from saliva are valuable for examining acute stress responses, this review suggests that specific targets may be valid and highlights specific areas of need for future research.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Salivary markers of inflammation in response to acute stress

Slavish

Graham‐Engeland

Smyth

2015

Brain, Behavior, and Immunity

216

201

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“…In most cases the feeling of dryness in only a subjective complaint and the examination of salivary flow and status of oral mucosa does not reveal abnormalities. In the present study women who complained of mouth dryness were free from ulcerations or severe oral inflammations [ 17 , 18 ]. It should also be noted that saliva is essential in the process of flavour recognition.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa

Rahnama¹,

Madej-Czerwonka²,

Jastrzębska-Jamrogiewicz³

et al. 2015

Self Cite

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Aim of the studyThe present study was aimed at estimating the prevalence of oral complications in cancer patients receiving chemotherapy.Material and methodsThe study was conducted on a group of 58 patients treated with chemotherapy (study group). The control group consisted of 30 healthy patients. Dental status and oral mucosa were examined using the criteria of the National Cancer Institute Toxicity Criteria Scale. The levels of stimulated and unstimulated saliva flow were analysed.ResultsIn the group of patients treated with chemotherapy, 59% of patients had inflammatory changes of the soft tissues of the mouth, such as erythema, erosions, or ulcers, which were discovered during dental examination. Such changes occurred in only 10% of patients in the control group. Six of the patients treated with chemotherapy reported pain with intensity was so severe that it caused swallowing difficulties. Patients in the study group frequently complained about the presence of dry mouth, taste disturbances, nausea, and vomiting. These symptoms occurred in 70% of patients undergoing oncological treatment. In both stimulated and unstimulated saliva secretion, the rates were significantly lower in patients from the research group, when compared to the control group.

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“…We previously suggested a significant association between salivary IL-1β and state anger score, supporting that mediators at a local site, as mouth, may indirectly influence emotional processing and changes in motivational state 28 . Likewise, the relationship of salivary IL-6 to psychosocial stress has successful previously demonstrated 21 , 22 . Interestingly, an important role for IL-18 has been proposed in the stress response.…”

Section: Introductionmentioning

confidence: 94%

“…Studies that have focused on correlations between salivary and blood-based inflammation were mainly conducted with static, baseline levels (i.e. not in response to stress) 22 , 23 . Nowadays, within the molecules involved in the inflammatory process, a moderate to strong association has been established only for the non-specific marker of the inflammation, C-reactive protein (CRP), between its serum and salivary levels (r = 0.72, p < 0.001) in non stressful context.…”

Section: Introductionmentioning

confidence: 99%

The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male

Fratta

Tatangelo

Campagna

et al. 2018

Sci Rep

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Saliva collection is considered a non-invasive method to detect inflammatory markers in response to emotional states within natural social contexts. Numerous studies have prompted an important role of cytokines in modulating distinct aspects of social and emotional behavior. The aim of this study was to investigate the reliability of plasma and saliva as investigative tools for measure some inflammatory marker levels (CRP, IL-1β, IL-18, and IL-6). At the same time, the relationships between these markers and emotional states in response to a socio-cognitive stress (Academic Exam, AE), were considered. It was demonstrated that the plasma and saliva concentrations of all immune-mediators analyzed were significantly related across the socio-cognitive stress. In addition, when there was a close correlation to AE, the anger state, the IL-1β, the IL-18 salivary and plasmatic concentrations were significantly higher, while they decreased during the AE. On the other hand, the anxiety state and the IL-6 levels significantly increased throughout the AE. The IL-1β and IL-6 were positively associated to the anger and the anxiety state, respectively. In conclusion, our data highlight that different immune markers are similarly detectable in plasma and saliva during socio-cognitive stress. Also, they could be related to different emotional responses.

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IL-1αand IL-1βLevels in Blood Serum and Saliva of Menopausal Women

Cited by 8 publications

References 19 publications

Salivary markers of inflammation in response to acute stress

Salivary markers of inflammation in response to acute stress

Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa

The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male

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