IL-1 Receptor Antagonist (IL-1RA) Gene Polymorphism in Sjogren's Syndrome and Rheumatoid Arthritis

Perrier, Stéphane; Coussediere, C.; Dubost, Jean Jacques; Albuisson, Éliane; Sauvezie, B

doi:10.1006/clin.1998.4520

Cited by 100 publications

(71 citation statements)

References 27 publications

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“…The serum levels of IL-1ra were markedly higher in primary SS patients than in controls, while the salivary levels were decreased [72]. TGF-b, which stimulates the IL-1ra production by monocytes, was strongly correlated with IL-1ra serum levels.…”

Section: Il-1 Receptor Antagonistmentioning

confidence: 84%

“…TGF-b, which stimulates the IL-1ra production by monocytes, was strongly correlated with IL-1ra serum levels. The IL1RN*2 allele has been suggested as a marker for more severe forms of SS [72]. TNF Mutational analysis of the 5 H -untranslated region (UTR) and 3 H -UTR of the mouse TNF-a gene reveals a marked degree of polymorphism.…”

Section: Il-1 Receptor Antagonistmentioning

confidence: 99%

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Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

et al. 2001

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Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are defined genetically as complex diseases where multiple genes are involved in their pathogenesis. Among the genes of interest are those coding for the cytokines, molecules involved in immunoregulation that have been shown to play important roles in these diseases. Whether abnormalities in cytokine production are owing to genetic polymorphisms within the genes themselves is a matter of intensive study. The finding of functional polymorphisms within cytokine genes and their potential association with disease will open new avenues in their treatment.

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Section: Il-1 Receptor Antagonistmentioning

confidence: 84%

Section: Il-1 Receptor Antagonistmentioning

confidence: 99%

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

et al. 2001

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“…The SNP rs419598 (IL1RA ϩ2018) is associated with several chronic inflammatory conditions including Sjögren's syndrome, alopecia areata, and atherosclerosis (30)(31)(32). It is also associated with pathologies of bone and joints, including osteoporotic fracture (33), and with susceptibility to RA (34,35).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

Gordon¹,

Kiss-Tóth²,

Stockley³

et al. 2008

Arthritis & Rheumatism

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Objective. To determine whether osteolysis after total hip arthroplasty (THA) is associated with common polymorphisms within the genes encoding the interleukin-1 (IL-1) family and IL-6, and to determine whether polymorphisms that are associated with osteolysis affect in vitro messenger RNA (mRNA) expression in human peripheral blood mononuclear cells (PBMCs) in response to wear particles.Methods. Unrelated white subjects of North European descent (n ‫؍‬ 612) were recruited a mean of 11 years after cemented THA for primary osteoarthritis. Of these subjects, 272 had previous osteolysis and 340 had no radiographic evidence of osteolysis (control group). Genomic DNA was genotyped for the following singlenucleotide polymorphisms (SNPs): IL1A ؉4845, IL1B ؉3954, IL1B -3737, IL1B -511, IL1RA ؉2018, IL6 -174, IL6 -572, and IL6 -597. In a subset of 60 subjects, PBMCs were extracted and stimulated with titanium particles and/or endotoxin, and cytokine mRNA expression was measured using quantitative real-time reverse transcriptase-polymerase chain reaction.Results. The odds ratio (OR) for osteolysis associated with carriage of the IL1RA ؉2018C allele was 0.66 (95% confidence interval [95% CI] 0.48-0.91) (P ‫؍‬ 0.012). The remaining SNPs were not individually associated with osteolysis. The uncommon IL6 haplotype ؊174G/؊572G/؊597A (osteolysis group frequency 2.4%, control group frequency 0.8%) was associated with osteolysis (P ‫؍‬ 0.02, calculated using Haploview software). The IL1RA ؉2018CC genotype was associated with increased mRNA expression compared with the ؉2018TT genotype in both unstimulated and stimulated PBMCs (P ‫؍‬ 0.01 by analysis of variance, after Bonferroni correction).Conclusion. The IL1RA ؉2018C allele is associated with a decreased risk of osteolysis after THA and with increased IL-1 receptor antagonist mRNA expression in vitro. An uncommon haplotype within the promoter region of the gene for IL-6 is positively associated with osteolysis.

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“…Further studies will be necessary to clarify the role of this polymorphism in breast cancer, especially its influence on systemic and local production of IL-1ra since we have previously found that IL-1RN * 2 allele accentuates the differential IL-1ra expression in blood and at the inflammatory site [46].…”

Section: Il-1 Family and Breast Cancermentioning

confidence: 99%

IL‐1 family in breast cancer: Potential interplay with leptin and other adipocytokines

2008

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Edited by Masayuki MiyasakaKeywords: IL-1 Leptin Adipocytokine Breast cancer Obesity a b s t r a c t Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

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IL-1 Receptor Antagonist (IL-1RA) Gene Polymorphism in Sjogren's Syndrome and Rheumatoid Arthritis

Cited by 100 publications

References 27 publications

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

Cytokine Polymorphisms in Systemic Lupus Erythematosus and Sjögren's Syndrome

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

IL‐1 family in breast cancer: Potential interplay with leptin and other adipocytokines

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